An Alkyne Rod to Constrain a Peptide Backbone in an Extended Conformation,European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

An Alkyne Rod to Constrain a Peptide Backbone in an Extended Conformation
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-21 , DOI: 10.1002/ejoc.201800979
Adam Přibylka ₁ , Viktor Krchňák _{1,

2}

Affiliation

A peptide backbone was locked in an extended conformation by the introduction of a dialkyne rod attached to amide nitrogens via one and/or two carbon spacers. Linear precursors were obtained by means of solid‐phase synthesis from commercially available building blocks. Subsequently, 13‐ to 15‐membered peptide macrocycles were obtained through Cu‐catalyzed cyclization in solution.