Superstructural Raman Nanosensors with Integrated Dual Functions for Ultrasensitive Detection and Tunable Release of Molecules,Chemistry of Materials

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Superstructural Raman Nanosensors with Integrated Dual Functions for Ultrasensitive Detection and Tunable Release of Molecules
Chemistry of Materials ( IF 7.2 ) Pub Date : 2018-06-29 00:00:00 , DOI: 10.1021/acs.chemmater.8b01979
Jing Liu _{1,

2} , Jianhe Guo ₁ , Guowen Meng _{2,

3} , Donglei Fan _{1,

4}

Affiliation

It is highly desirable but extremely difficult to actively control the release dynamics of molecules from nanoparticle carriers and monitor the release process in real time. In this work, we report the design, fabrication, and manipulation of a superstructural Raman nanosensor, offering integrated dual functions in ultrasensitive biodetection and dynamic control in molecule release. The device has a designed porous superstructure consisting of gold (Au) nanorod cores and silica shells embedded with arrays of nanocavities arranged in concentric layers in three-dimensions (3D), where high-density plasmonic silver (Ag) nanoparticles are grown both in the nanocavities and on the outer surfaces. The Ag nanoparticles provide substantially enhanced Raman sensitivity for detection of molecules owing to the large number of hotspots as well as the near-field coupling of Ag nanoparticles due to their 3D concentric arrangement. Furthermore, by controlling the external electric field, the release of molecules can be facilely controlled at tunable rates owing to the induced electrokinetics at the junctions of Ag nanoparticles. Finally, the biosensing-release-unibody devices can be readily motorized, including transport and rotation, which opens new opportunities for single-cell bioresearch and precision medicine.

中文翻译：

具有双重功能的超结构拉曼纳米传感器，用于分子的超灵敏检测和可调释放

主动地控制分子从纳米颗粒载体的释放动力学并实时监测释放过程是非常需要的，但是极其困难。在这项工作中，我们报告了超结构拉曼纳米传感器的设计，制造和操作，在超灵敏生物检测和分子释放的动态控制方面提供了集成的双重功能。该设备具有设计的多孔上部结构，该上部结构由金（Au）纳米棒核和二氧化硅壳组成，嵌有纳米腔阵列，这些纳米腔阵列以三维（3D）的方式排列在同心层中，高密度等离子银（Ag）纳米颗粒均生长在纳米颗粒中。纳米腔和外表面。由于大量的热点以及由于其3D同心排列的银纳米颗粒的近场耦合，银纳米颗粒为检测分子提供了显着增强的拉曼灵敏度。此外，通过控制外部电场，由于在银纳米颗粒的接合处感应的电动势，可以以可调的速率容易地控制分子的释放。最后，生物传感释放一体式设备可以很容易地实现机动化，包括运输和旋转，这为单细胞生物研究和精密医学打开了新的机遇。由于在银纳米颗粒的交界处引起的电动势，因此可以以可调的速率容易地控制分子的释放。最后，生物传感释放一体式设备可以很容易地实现机动化，包括运输和旋转，这为单细胞生物研究和精密医学打开了新的机遇。由于在银纳米颗粒的交界处引起的电动势，因此可以以可调的速率容易地控制分子的释放。最后，生物传感释放一体式设备可以很容易地实现机动化，包括运输和旋转，这为单细胞生物研究和精密医学打开了新的机遇。

更新日期：2018-06-29

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