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Block Copolymer Micelles in Nanomedicine Applications
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-06-29 00:00:00 , DOI: 10.1021/acs.chemrev.8b00199 Horacio Cabral , Kanjiro Miyata , Kensuke Osada , Kazunori Kataoka 1, 2
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-06-29 00:00:00 , DOI: 10.1021/acs.chemrev.8b00199 Horacio Cabral , Kanjiro Miyata , Kensuke Osada , Kazunori Kataoka 1, 2
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Polymeric micelles are demonstrating high potential as nanomedicines capable of controlling the distribution and function of loaded bioactive agents in the body, effectively overcoming biological barriers, and various formulations are engaged in intensive preclinical and clinical testing. This Review focuses on polymeric micelles assembled through multimolecular interactions between block copolymers and the loaded drugs, proteins, or nucleic acids as translationable nanomedicines. The aspects involved in the design of successful micellar carriers are described in detail on the basis of the type of polymer/payload interaction, as well as the interplay of micelles with the biological interface, emphasizing on the chemistry and engineering of the block copolymers. By shaping these features, polymeric micelles have been propitious for delivering a wide range of therapeutics through effective sensing of targets in the body and adjustment of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level. Finally, the future perspectives and imminent challenges for polymeric micelles as nanomedicines are discussed, anticipating to spur further innovations.
中文翻译：
纳米医学应用中的嵌段共聚物胶束
高分子胶束作为纳米药物具有很高的潜力，可以控制体内负载的生物活性剂的分布和功能，有效克服生物屏障，并且各种制剂都参与了深入的临床前和临床测试。这篇评论集中在通过嵌段共聚物与作为可翻译纳米药物的负载药物，蛋白质或核酸之间的多分子相互作用而组装的聚合物胶束。基于聚合物/有效负载相互作用的类型以及胶束与生物界面的相互作用，重点介绍了成功的胶束载体设计的各个方面，重点是嵌段共聚物的化学和工程学。通过塑造这些功能，聚合胶束通过有效地感测体内靶标并响应特定刺激来调节其性质，从而调节了靶标位置（甚至在亚细胞水平）的负载药物活性，从而有利于提供广泛的治疗方法。最后，讨论了高分子胶束作为纳米药物的未来前景和迫在眉睫的挑战，以期推动进一步的创新。
更新日期：2018-06-29
中文翻译：
纳米医学应用中的嵌段共聚物胶束
高分子胶束作为纳米药物具有很高的潜力，可以控制体内负载的生物活性剂的分布和功能，有效克服生物屏障，并且各种制剂都参与了深入的临床前和临床测试。这篇评论集中在通过嵌段共聚物与作为可翻译纳米药物的负载药物，蛋白质或核酸之间的多分子相互作用而组装的聚合物胶束。基于聚合物/有效负载相互作用的类型以及胶束与生物界面的相互作用，重点介绍了成功的胶束载体设计的各个方面，重点是嵌段共聚物的化学和工程学。通过塑造这些功能，聚合胶束通过有效地感测体内靶标并响应特定刺激来调节其性质，从而调节了靶标位置（甚至在亚细胞水平）的负载药物活性，从而有利于提供广泛的治疗方法。最后，讨论了高分子胶束作为纳米药物的未来前景和迫在眉睫的挑战，以期推动进一步的创新。
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