Recent Advances in Transition-Metal-Catalyzed/Mediated Transformations of Vinylidenecyclopropanes,Accounts of Chemical Research

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Recent Advances in Transition-Metal-Catalyzed/Mediated Transformations of Vinylidenecyclopropanes
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-06-29 00:00:00 , DOI: 10.1021/acs.accounts.8b00171
Song Yang ₁ , Min Shi _{1,

2,

3}

Affiliation

Vinylidenecyclopropanes (VDCPs), having an allene moiety connected to a highly strained cyclopropyl group, have attracted a substantial amount of attention since they are fascinating building blocks for organic synthesis. During recent years, the reactions of VDCPs in the presence of a Lewis acid or a Brønsted acid and those induced by heat or light have experienced significant advancements due to the unique structural and electronic properties of VDCPs. Transition-metal-catalyzed reactions of VDCPs were not intensely investigated until the last 5 years. Recently, significant progress has been made in transition-metal-catalyzed transformations of VDCPs, and they have emerged as a new direction for the chemistry of strained small rings, especially when new types of functionalized vinylidenecyclopropanes (FVDCPs) are used as substrates. To date, many interesting transformations have been explored using these novel VDCPs under the catalysis of transition metals, such as gold, palladium, or rhodium, and various novel and useful heterocyclic or polycyclic compounds have been generated. These new findings have enriched the chemistry of strained small carbocycles.

中文翻译：

亚乙烯基环丙烷的过渡金属催化/介导转化的最新进展

具有连接至高度应变的环丙基的丙二烯部分的亚乙烯基亚环丙烷（VDCP），由于它们是有机合成的引人入胜的组成部分，因此吸引了相当多的关注。近年来，由于VDCPs独特的结构和电子特性，在路易斯酸或布朗斯台德酸存在下，VDCPs的反应以及由热或光诱导的反应已经取得了显着进展。直到最近5年，才对VDCP的过渡金属催化反应进行了深入研究。最近，在过渡金属催化的VDCPs转化中取得了重大进展，它们已成为应变小环化学反应的新方向，特别是当新型新型官能化亚乙烯基亚环丙烷（FVDCPs）用作底物时。迄今为止，在过渡金属（例如金，钯或铑）的催化下，使用这些新颖的VDCP探索了许多有趣的转变，并且已生成了各种新颖且有用的杂环或多环化合物。这些新发现丰富了应变小的碳环化合物的化学性质。

更新日期：2018-06-29

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