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WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis
Environment International ( IF 10.3 ) Pub Date : 2018-06-27 , DOI: 10.1016/j.envint.2018.06.005
Daniele Mandrioli 1 , Vivi Schlünssen 2 , Balázs Ádám 3 , Robert A Cohen 4 , Claudio Colosio 5 , Weihong Chen 6 , Axel Fischer 7 , Lode Godderis 8 , Thomas Göen 9 , Ivan D Ivanov 10 , Nancy Leppink 11 , Stefan Mandic-Rajcevic 12 , Federica Masci 12 , Ben Nemery 8 , Frank Pega 10 , Annette Prüss-Üstün 10 , Daria Sgargi 13 , Yuka Ujita 11 , Stevie van der Mierden 1 , Muzimkhulu Zungu 14 , Paul T J Scheepers 15
Affiliation  

Background

The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years attributable to pneumoconiosis from occupational exposure to dusts and/or fibres, to inform the development of the WHO/ILO joint methodology.

Objectives

We aim to systematically review studies on occupational exposure to dusts and/or fibres (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework.

Data sources

Separately for Systematic Reviews 1 and 2, we will search electronic academic databases for potentially relevant records from published and unpublished studies, including Medline, EMBASE, Web of Science and CISDOC. We will also search electronic grey literature databases, Internet search engines and organizational websites; hand-search reference list of previous systematic reviews and included study records; and consult additional experts.

Study eligibility and criteria

We will include working-age (≥15 years) study participants in the formal and informal economy in any WHO and/or ILO Member State but exclude children (<15 years) and unpaid domestic workers. Eligible risk factors will be dusts and/or fibres from: (i) asbestos; (ii) silica; and/or (iii) coal (defined as pure coal dust and/or dust from coal mining). Included outcomes will be (i) asbestosis; (ii) silicosis; (iii) coal worker pneumoconiosis; and (iv) unspecified pneumoconiosis. For Systematic Review 1, we will include quantitative prevalence studies of occupational exposure to dusts and/or fibres (i.e. no versus any exposure) stratified by country, sex, age and industrial sector or occupation. For Systematic Review 2, we will include randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies with an estimate of any occupational exposure to dusts and/or fibres on the prevalence of, incidence of or mortality due to pneumoconiosis, compared with the theoretical minimum risk exposure level of no exposure.

Study appraisal and synthesis methods

At least two review authors will independently screen titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, followed by extraction of data from qualifying studies. At least two review authors will assess risk of bias and the quality of evidence, using the most suited tools currently available. For Systematic Review 2, if feasible, we will combine relative risks using meta-analysis. We will report results using the guidelines for accurate and transparent health estimates reporting (GATHER) for Systematic Review 1 and the preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) for Systematic Review 2.

PROSPERO registration number

CRD42018084131.



中文翻译:

世卫组织/国际劳工组织与工作相关的疾病和伤害负担:系统评价职业接触粉尘和/或纤维以及职业接触粉尘和/或纤维对尘肺的影响的协议

背景

世界卫生组织 (WHO) 和国际劳工组织 (ILO) 正在开发一种联合方法,用于估计国家和全球与工作相关的疾病和伤害负担(WHO/ILO 联合方法),该方法来自大型专家网络. 在本文中,我们提出了两项​​系统评价参数的方案,以估计因职业接触粉尘和/或纤维而引起的尘肺病死亡人数和伤残调整寿命年数,为 WHO/ILO 联合方法的发展提供信息.

目标

我们的目标是系统地回顾关于职业暴露于粉尘和/或纤维的研究(系统回顾 1),并系统回顾和荟萃分析评估职业暴露于粉尘和/或纤维对尘肺的影响(系统回顾 2),应用导航指南系统评价方法作为一个组织框架。

数据源

对于系统评价 1 和 2,我们将分别在电子学术数据库中搜索已发表和未发表研究的潜在相关记录,包括 Medline、EMBASE、Web of Science 和 CISDOC。我们还将搜索电子灰色文献数据库、互联网搜索引擎和组织网站;手动搜索以前系统评价的参考列表和包含的研究记录;并咨询其他专家。

研究资格和标准

我们将包括任何世卫组织和/或国际劳工组织成员国正规和非正规经济中的工作年龄(≥15 岁)研究参与者,但不包括儿童(<15 岁)和无薪家庭工人。符合条件的风险因素将是来自: (i) 石棉的灰尘和/或纤维;(ii) 二氧化硅;和/或 (iii) 煤(定义为纯煤尘和/或来自煤矿开采的粉尘)。包括的结果将是 (i)石棉沉着症; (ii) 矽肺;(iii) 煤工尘肺;(iv) 未指明的尘肺病。对于系统评价 1,我们将包括按国家、性别、年龄和工业部门或职业分层的职业接触粉尘和/或纤维(即没有与任何接触)的定量流行率研究。对于系统评价 2,我们将包括随机对照试验、队列研究、病例对照研究和其他非随机干预研究,以估计任何职业接触粉尘和/或纤维对以下因素的患病率、发病率或死亡率的影响尘肺病,与没有接触的理论最低风险接触水平相比。

研究评价与综合方法

至少有两名综述作者将在第一阶段根据资格标准独立筛选标题和摘要,在第二阶段独立筛选可能符合条件的记录的全文,然后从符合条件的研究中提取数据。至少有两名综述作者将使用目前可用的最合适的工具评估偏倚风险和证据质量。对于系统评价 2,如果可行,我们将使用荟萃分析结合相对风险。我们将使用系统评价 1 的准确和透明的健康估计报告指南 (GATHER) 和系统评价 2 的系统评价和荟萃分析指南 (PRISMA) 的首选报告项目报告结果。

PROSPERO 注册号

CRD42018084131。

更新日期:2018-07-12
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