Hydrated Phospholipid Polymer Gel-Like Layer for Increased Durability of Orthopedic Bearing Surfaces.,Langmuir

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Hydrated Phospholipid Polymer Gel-Like Layer for Increased Durability of Orthopedic Bearing Surfaces.
Langmuir ( IF 3.7 ) Pub Date : 2018-06-29 00:00:00 , DOI: 10.1021/acs.langmuir.8b01494
Masayuki Kyomoto _{1,

2,

3} , Toru Moro _{2,

4} , Shihori Yamane _{1,

2,

3} , Kenichi Watanabe _{2,

3} , Masami Hashimoto ₅ , Sakae Tanaka ₄ , Kazuhiko Ishihara ₁

Affiliation

Recently, traditional strategies for manipulating orthopedic bearing substrates have attempted to improve their wear resistance by adjusting polyethylene substrate through cross-linking and antioxidant blending. However, further research is required on the substrate, as well as the surface focused on the structure and role of articular cartilage. We therefore develop an orthopedic bearing surface comprising a nanometer-scale hydrated gel-like layer by grafting highly hydrophilic poly(2-methacryloyloxyethyl phosphorylcholine), with the aim of mimicking the lubrication mechanism of articular cartilage, and investigate its surface characteristics, bulk characteristics, and behavior under load bearing conditions upon accelerated aging. Neither the hydrophilicity nor lubricity of the gel-like surface was influenced by accelerated aging; instead, high stability was revealed, even under strong oxidation conditions. The characteristics of the hydrated gel-like surface potentiated the wear resistance of the cross-linked polyethylene liner, irrespective of accelerated aging. These results suggest that the hydrated gel-like surface enhances the longevity of cross-linked polyethylene bearings even under load-bearing conditions. Furthermore, the inflection point on the time series of wear can be a suitable indicator of the durability of the life-long protectant. In conclusion, the hydrated gel-like surface can positively increase orthopedic implant durability.

中文翻译：

水合的磷脂聚合物凝胶状涂层，可提高骨科轴承表面的耐用性。

近来，用于操纵整形外科手术的骨科基材的传统策略已经尝试通过通过交联和抗氧化剂共混来调节聚乙烯基材来改善其耐磨性。但是，需要进一步研究基底以及聚焦于关节软骨的结构和作用的表面。因此，我们通过接枝高度亲水性的聚（2-甲基丙烯酰氧基氧乙基磷酸胆碱），开发了一种包含纳米级水合凝胶状层的整形外科手术支撑表面，目的是模拟关节软骨的润滑机理，并研究其表面特性，体积特性，加速老化时在负载条件下的性能和行为。凝胶状表面的亲水性和润滑性均不受加速老化的影响。反而，即使在强氧化条件下也显示出高稳定性。水合凝胶状表面的特性增强了交联聚乙烯衬里的耐磨性，而与加速老化无关。这些结果表明，即使在承重条件下，水合的凝胶状表面也可提高交联聚乙烯轴承的寿命。此外，磨损的时间序列上的拐点可以作为终身保护剂耐久性的合适指标。总之，水合的凝胶状表面可以肯定地增加整形外科植入物的耐用性。这些结果表明，即使在承重条件下，水合的凝胶状表面也可提高交联聚乙烯轴承的寿命。此外，磨损的时间序列上的拐点可以作为终身保护剂耐久性的合适指标。总之，水合的凝胶状表面可以肯定地增加整形外科植入物的耐用性。这些结果表明，即使在承重条件下，水合的凝胶状表面也可提高交联聚乙烯轴承的寿命。此外，磨损的时间序列上的拐点可以作为终身保护剂耐久性的合适指标。总之，水合的凝胶状表面可以肯定地增加整形外科植入物的耐用性。

更新日期：2018-06-29

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