A Transferrin Triggered Pathway for Highly Targeted Delivery of Graphene‐Based Nanodrugs to Treat Choroidal Melanoma,Advanced Healthcare Materials

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A Transferrin Triggered Pathway for Highly Targeted Delivery of Graphene‐Based Nanodrugs to Treat Choroidal Melanoma
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-06-29 , DOI: 10.1002/adhm.201800377
Bingxin Zhao ₁ , Kalun Dong ₁ , Mimi Lin ₁ , Gongxian Dong ₁ , Suyan Shan ₁ , Tom Lawson ₂ , Lu Yan ₁ , Wenjing Zhang ₁ , Bingyang Shi ₃ , Shulei Chou ₄ , Mark S. Baker ₃ , Yong Liu ₁

Affiliation

The synthesis of transferrin (Tf)‐modified pegylated graphene (PG) and its application as a highly efficient drug delivery carrier for therapy of Ocular Choroidal Melanoma‐1 (OCM‐1) cells is presented. For the first reported time, nanoscaled PG is prepared using an environmentally friendly ball‐milling technique. The unique 2D nanostructure obtained using this PG synthesis approach offers considerable advantages in terms of drug loading and delivery, as well as the conjugation of Tf to PG providing a more targeted delivery vehicle. A highly efficient targeted pathway toward OCM‐1 cells triggered by an affinity between Tf and Tf receptors expressed on the surface of OCM‐1 cells is reported first here. PG‐Tf is observed to easily anchor anticancer drugs such as doxorubicin via π–π stacking. This work performs a Transwell two cells coculture experiment, a 3D in vitro tumor model, and an in vivo mouse model with OCM‐1 tumors to demonstrate the composite's therapeutic superiority over conventional systems for the targeted delivery and controlled release of antitumor drugs.

中文翻译：

转铁蛋白触发的途径，可高度靶向地输送基于石墨烯的纳米药物，以治疗脉络膜黑色素瘤

本文介绍了转铁蛋白（Tf）修饰的聚乙二醇化石墨烯（PG）的合成及其作为眼科脉络膜黑色素瘤-1（OCM-1）细胞治疗的高效药物递送载体的应用。首次报道，使用环保的球磨技术制备了纳米级PG。使用这种PG合成方法获得的独特2D纳米结构在药物装载和输送方面以及Tf与PG的缀合方面提供了相当大的优势，从而提供了更具针对性的输送载体。本文首先报道了一种由Ofm-1细胞表面表达的Tf和Tf受体之间的亲和力触发的，通向OCM-1细胞的高效靶向途径。观察到PG-Tf可通过π-π堆叠轻松锚定阿霉素等抗癌药物。

更新日期：2018-06-29

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