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Novel Targets for Parkinson's Disease: Addressing Different Therapeutic Paradigms and Conundrums.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-07-11 , DOI: 10.1021/acschemneuro.8b00180 Pallavi Rane 1 , Deepaneeta Sarmah 1 , Shashikala Bhute 1 , Harpreet Kaur 1 , Avirag Goswami 2 , Kiran Kalia 1 , Anupom Borah 3 , Kunjan R Dave 2 , Nutan Sharma 4 , Pallab Bhattacharya 1
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-07-11 , DOI: 10.1021/acschemneuro.8b00180 Pallavi Rane 1 , Deepaneeta Sarmah 1 , Shashikala Bhute 1 , Harpreet Kaur 1 , Avirag Goswami 2 , Kiran Kalia 1 , Anupom Borah 3 , Kunjan R Dave 2 , Nutan Sharma 4 , Pallab Bhattacharya 1
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Parkinson's disease (PD) is a neurodegenerative disease that is pathologically characterized by degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc). PD leads to clinical motor features that include rigidity, tremor, and bradykinesia. Despite multiple available therapies for PD, the clinical features continue to progress, and patients suffer progressive disability. Many advances have been made in PD therapy which directly target the cause of the disease rather than providing symptomatic relief. A neuroprotective or disease modifying strategy that can slow or cease clinical progression and worsening disability remains as a major unmet medical need for PD management. The present review discusses potential novel therapies for PD that include recent interventions in the form of immunomodulatory techniques and stem cell therapy. Further, an introspective approach to identify numerous other novel targets that can alleviate PD pathogenesis and enable physicians to practice multitargeted therapy and that may provide a ray of hope to PD patients in the future are discussed.
中文翻译：
帕金森氏病的新目标：解决不同的治疗范例和难题。
帕金森氏病（PD）是一种神经退行性疾病，其病理特征是黑质致密部（SNpc）中的多巴胺神经元变性。PD可导致临床运动功能，包括僵硬，震颤和运动迟缓。尽管有多种可用的PD治疗方法，但临床特征仍在继续发展，并且患者患有进行性残疾。PD疗法已经取得了许多进展，这些进展直接针对疾病的原因而不是提供症状缓解。可以减慢或停止临床进展并加剧残疾的神经保护或疾病改变策略仍然是PD治疗的主要未满足医学需求。本综述讨论了PD的潜在新疗法，包括以免疫调节技术和干细胞疗法的形式进行的近期干预。此外，讨论了一种内省性方法，用于确定许多其他可以减轻PD发病机理并使医生能够实施多靶点治疗的新型靶标，并可能为PD患者将来带来一线希望。
更新日期：2018-06-29
中文翻译：
帕金森氏病的新目标：解决不同的治疗范例和难题。
帕金森氏病（PD）是一种神经退行性疾病，其病理特征是黑质致密部（SNpc）中的多巴胺神经元变性。PD可导致临床运动功能，包括僵硬，震颤和运动迟缓。尽管有多种可用的PD治疗方法，但临床特征仍在继续发展，并且患者患有进行性残疾。PD疗法已经取得了许多进展，这些进展直接针对疾病的原因而不是提供症状缓解。可以减慢或停止临床进展并加剧残疾的神经保护或疾病改变策略仍然是PD治疗的主要未满足医学需求。本综述讨论了PD的潜在新疗法，包括以免疫调节技术和干细胞疗法的形式进行的近期干预。此外，讨论了一种内省性方法，用于确定许多其他可以减轻PD发病机理并使医生能够实施多靶点治疗的新型靶标，并可能为PD患者将来带来一线希望。
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