DARK Classics in Chemical Neuroscience: Psilocybin,ACS Chemical Neuroscience

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DARK Classics in Chemical Neuroscience: Psilocybin
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-06-29 00:00:00 , DOI: 10.1021/acschemneuro.8b00186
Haden A. Geiger ₁ , Madeline G. Wurst ₁ , R. Nathan Daniels _{1,

2}

Affiliation

Psilocybin is found in a family of mushrooms commonly known as “magic mushrooms” that have been used throughout history to induce hallucinations. In the late 1950s Albert Hofmann, of Sandoz Laboratories, identified and synthesized the psychoactive compounds psilocybin and psilocin which are found in psilocybe mushrooms. Psilocybin was marketed by Sandoz as Indocybin for basic psychopharmacological and therapeutic clinical research. Psilocybin saw a rapid rise in popularity during the 1960s and was classed as a Schedule I drug in 1970. This led to a significant decrease in psilocybin research. Recently, however, preliminary studies with psilocybin have shown promise as potential for the treatment of obsessive compulsive disorder, alcohol addiction, tobacco addiction, and major depressive disorder, and the treatment of depression in terminally ill cancer patients. This review describes in detail the synthesis, metabolism, pharmacology, adverse drug reactions, and importance of psilocybin to neuroscience in the past and present.

中文翻译：

化学神经科学中的暗黑经典：菌素胞苷

菌丝素存在于蘑菇家族中，通常被称为“魔术蘑菇”，在整个历史中一直被用来诱导幻觉。在1950年代后期，Sandoz Laboratories的Albert Hofmann鉴定并合成了在psilocybe蘑菇中发现的精神活性化合物psilocybin和psilocin。Sandoz出售的Pyilocybin被称为Indocybin，用于基本的心理药理学和治疗性临床研究。介孢菌素在1960年代迅速普及，并在1970年被列为附表I药物。这导致介孢菌素的研究显着减少。但是，最近，对psilocybin进行的初步研究表明，有望将其用于治疗强迫症，酒精成瘾，烟草成瘾和重度抑郁症，以及对绝症患者的抑郁症的治疗。这篇综述详细描述了过去和现在的合成，代谢，药理学，药物不良反应以及psilocybin对神经科学的重要性。

更新日期：2018-06-29

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