Radiotherapy is a vitally important strategy for clinical treatment of malignant cancers. Therefore, rational design and development of radiosensitizers that could enhance radiotherapeutic efficacy has attracted tremendous attention. Antiangiogenic therapy could be a potentially effective strategy to regulate tumor growth and metastasis since angiogenesis plays a pivotal role in tumor growth, invasion and metastasis to other organs. Herein, we have rationally designed a smart and effective nanosystem by combining ultrasmall selenium nanoparticles and bevacizumab (Avastin™, Av), for simultaneous radiotherapy and antiangiogenic therapy of cancer. The nanosystem was further coated with red blood cell (RBC) membranes to develop the final construct, RBCs@Se/Av. The RBC membrane coating effectively prolongs the blood circulation time and reduces the elimination of the nanosystem by autoimmune responses. As expected, RBCs@Se/Av, when irradiated with X-rays demonstrated potent anticancer and antiangiogenic responses in vitro and in vivo, as evidenced by the strong inhibition of A375 tumor growth in nude mice, without causing any obvious histological damage to the non-target major organs. Taken together, this study demonstrates an effective strategy for the design of a smart Se-based nanosystem decorated with the RBC membrane for simultaneous cancer radiosensitization and precise antiangiogenesis.

中文翻译：

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高度血液相容性红细胞膜包被超小型硒纳米系统，可同时实现癌症放射增敏和精确抗血管生成†

放射治疗是临床治疗恶性肿瘤的重要策略。因此，合理设计和开发能够提高放射治疗效果的放射增敏剂引起了极大的关注。抗血管生成治疗可能是调节肿瘤生长和转移的潜在有效策略，因为血管生成在肿瘤生长、侵袭和转移到其他器官中起着关键作用。在此，我们通过结合超小硒纳米颗粒和贝伐单抗（Avastin™，Av）合理设计了一种智能且有效的纳米系统，用于癌症的同步放射治疗和抗血管生成治疗。该纳米系统进一步涂有红细胞 (RBC) 膜，以开发最终的构建体 RBCs@Se/Av。红细胞膜涂层有效延长血液循环时间，减少自身免疫反应对纳米系统的消除。正如预期的那样，RBCs@Se/Av 在受到 X 射线照射时，在体外和体内表现出有效的抗癌和抗血管生成反应，对裸鼠 A375 肿瘤生长的强烈抑制证明了这一点，并且不会对非裸鼠造成任何明显的组织学损伤。 -针对主要器官。总而言之，这项研究展示了一种设计智能硒基纳米系统的有效策略，该系统装饰有红细胞膜，可同时实现癌症放射增敏和精确的抗血管生成。