Palladium-catalyzed chemoselective anaerobic oxidation of N-heterocycle-containing alcohols†,Organic Chemistry Frontiers

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Palladium-catalyzed chemoselective anaerobic oxidation of N-heterocycle-containing alcohols†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-06-29 00:00:00 , DOI: 10.1039/c8qo00421h
Masami Kuriyama _{1,

2,

3,

4} , Sho Nakashima _{1,

2,

3,

4} , Tsubasa Miyagi _{1,

2,

3,

4} , Kanako Sato _{1,

2,

3,

4} , Kosuke Yamamoto _{1,

2,

3,

4} , Osamu Onomura _{1,

2,

3,

4}

Affiliation

The palladium-catalyzed anaerobic oxidation for N-heterocycle-containing alcohols has been developed with chloroarenes as oxidants. In this process, primary and secondary alcohols were selectively oxidized even in the presence of cyclic amines as well as heteroarenes, and primary, secondary, and tertiary amino groups were found to be well tolerated. Moreover, a gram-scale chemoselective oxidation was achieved in addition to a double oxidation of a diamino diol.

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