An efficient iodine pentoxide-triggered iodocarbocyclization for the synthesis of iodooxindoles in water†,Organic & Biomolecular Chemistry

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An efficient iodine pentoxide-triggered iodocarbocyclization for the synthesis of iodooxindoles in water†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-06-28 00:00:00 , DOI: 10.1039/c8ob01130c
Ming-Zhong Zhang _{1,

2,

3,

4} , Xin Wang _{1,

2,

3,

4} , Ming-Ying Gong _{1,

2,

3,

4} , Lin Chen _{1,

2,

3,

4} , Wen-Bing Shi _{1,

2,

3,

4} , Shu-Hua He _{1,

2,

3,

4} , Yong Jiang _{1,

2,

3,

4} , Tieqiao Chen _{4,

5,

6,

7,

8}

Affiliation

An efficient iodocarbocyclization of alkenes for the synthesis of iodooxindoles has been developed. This reaction proceeds in a chemoselective manner and shows excellent tolerance of various functional groups, including a chemosensitive hydroxymethyl group. Nonmetal inorganic iodine pentoxide was used as both the oxidant and iodine source, making this protocol very practical. On the basis of experimental observations, a plausible electrophilic reaction mechanism was proposed.

中文翻译：

一种有效的五氧化二碘触发的碘碳环化反应，用于水中碘代吲哚的合成†

已经开发了用于合成碘代吲哚的烯烃的有效碘碳环化。该反应以化学选择性方式进行，并且显示出对包括化学敏感性羟甲基在内的各种官能团的优异耐受性。非金属无机五氧化二碘被用作氧化剂和碘源，这使该协议非常实用。在实验观察的基础上，提出了合理的亲电反应机理。

更新日期：2018-06-28

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