Spontaneous domain formation in disordered copolymers as a mechanism for chromosome structuring†,Soft Matter

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Spontaneous domain formation in disordered copolymers as a mechanism for chromosome structuring†
Soft Matter ( IF 2.9 ) Pub Date : 2018-06-28 00:00:00 , DOI: 10.1039/c8sm00468d
Matteo Negri _{1,

2,

3,

4} , Marco Gherardi _{1,

2,

3,

4} , Guido Tiana _{1,

2,

3,

4,

5} , Marco Cosentino Lagomarsino _{6,

7,

8,

9,

10}

Affiliation

Motivated by the problem of domain formation in chromosomes, we studied a co-polymer model where only a subset of the monomers feel attractive interactions. These monomers are displaced randomly from a regularly-spaced pattern, thus introducing some quenched disorder in the system. Previous work has shown that in the case of regularly-spaced interacting monomers this chain can fold into structures characterized by multiple distinct domains of consecutive segments. In each domain, attractive interactions are balanced by the entropy cost of forming loops. We show by advanced replica-exchange simulations that adding disorder in the position of the interacting monomers further stabilizes these domains. The model suggests that the partitioning of the chain into well-defined domains of consecutive monomers is a spontaneous property of heteropolymers. In the case of chromosomes, evolution could have acted on the spacing of interacting monomers to modulate in a simple way the underlying domains for functional reasons.

中文翻译：

无序共聚物中的自发结构域形成是染色体结构的机制†

受染色体中域形成问题的影响，我们研究了一种共聚物模型，其中只有一部分单体感觉到有吸引力的相互作用。这些单体从规则间隔的图案中随机移位，从而在系统中引入一些猝灭的紊乱。先前的工作表明，在规则间隔的相互作用单体的情况下，该链可以折叠成以连续节段的多个不同结构域为特征的结构。在每个域中，有吸引力的交互作用通过形成循环的熵代价得到平衡。我们通过先进的副本交换模拟显示，在相互作用的单体位置中增加无序性可以进一步稳定这些域。该模型表明，将链划分为连续单体的明确定义的域是杂聚物的自发特性。

更新日期：2018-06-28

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