Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophytes, and yeast, and is the most common nail disorder seen in clinical practice. It is an important problem because it may cause local pain, paresthesias, difficulties performing activities of daily living, and impair social interactions. The epidemiology, risk factors, and clinical presentation and diagnosis of onychomycosis were discussed in the first article in this continuing medical education series. In this article, we review the prognosis and response to onychomycosis treatment, medications for onychomycosis that have been approved by the US Food and Drug Administration, and off-label therapies and devices. Methods to prevent onychomycosis recurrences and emerging therapies are also described.

甲癣是由皮肤癣菌，非皮肤癣菌和酵母菌引起的真菌性指甲感染，是临床实践中最常见的指甲疾病。这是一个重要的问题，因为它可能导致局部疼痛，感觉异常，执行日常生活活动的困难并削弱社交互动。在这一继续医学教育系列的第一篇文章中，讨论了甲癣的流行病学，危险因素以及临床表现和诊断。在本文中，我们回顾了甲癣治疗的预后和反应，已获得美国食品和药物管理局批准的甲癣药物以及标签外疗法和设备。还介绍了预防灰指甲复发和新兴疗法的方法。