A method is reported for synthesizing hollow silica spheres (HSS) using skimmed natural rubber (NR) latex as template. Tetraethyl orthosilicate (TEOS) and (3-aminopropyl) triethoxysilane (APTES) were used as the silica source and the co-structure directing agent, respectively. Effects of the TEOS/APTES mole ratio, the synthesis pH, and the total silica content relative to rubber, on HSS formation were observed through transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Skimmed NR latex proved to be a suitable natural template because the rubber particles in it were generally spherical and the ammonia (NH₃) conventionally added to the latex as a preservative served as the catalyst for the synthesis of silica. The suitable pH range for forming the hollow structures was 7–10, so long as the TEOS/APTES mole ratio was satisfactory and the total silica available was sufficient. The optimal conditions for forming HSS with robust shells were a TEOS/APTES mole ratio of 1:1, pH 10, and a total silica content of 200 phr. The silver-loaded HSS had excellent antibacterial activity against Escherichia coli.

报道了一种使用脱脂天然橡胶（NR）胶乳作为模板合成空心二氧化硅球（HSS）的方法。原硅酸四乙酯（TEOS）和（3-氨基丙基）三乙氧基硅烷（APTES）分别用作二氧化硅源和共结构导向剂。通过透射电子显微镜（TEM）和扫描电子显微镜（SEM）观察到TEOS / APTES摩尔比，合成pH和相对于橡胶的总二氧化硅含量对HSS的影响。脱脂的NR乳胶被证明是合适的天然模板，因为其中的橡胶颗粒通常为球形，氨气（NH ₃）通常作为防腐剂添加到胶乳中作为合成二氧化硅的催化剂。只要TEOS / APTES摩尔比令人满意，并且可用的总二氧化硅足够，则形成空心结构的合适pH范围是7-10。形成具有坚固外壳的HSS的最佳条件是TEOS / APTES摩尔比为1：1，pH为10，总二氧化硅含量为200 phr。载银的HSS对大肠杆菌具有优异的抗菌活性。