Perfluoroalkyl substances (PFASs) are known to accumulate in traditional food animals of the Arctic, and arctic indigenous peoples may be exposed via consumption of subsistence-harvested animals. PFASs are suspected of disrupting thyroid hormone homeostasis in humans. The aim of this study is to assess the relationship between serum PFASs and thyroid function in a remote population of Alaska Natives. Serum samples were collected from 85 individuals from St. Lawrence Island, Alaska. The concentrations of 13 PFASs, as well as free and total thyroxine (T4), free and total triiodothyronine (T3), and thyrotropin (TSH) were quantified in serum samples. The relationships between circulating concentrations of PFASs and thyroid hormones were assessed using multiple linear regression fit with generalized estimating equations. Several PFASs, including perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA), were positively associated with TSH concentrations when modeled individually. PFOS and PFNA were significantly associated with free T3 and PFNA was significantly associated with total T3 in models with PFAS*sex interactive terms; these associations suggested negative associations in men and positive associations in women. PFASs were not significantly associated with concentrations of free or total T4. Serum PFASs are associated with circulating thyroid hormone concentrations in a remote population of Alaska Natives. The effects of PFAS exposure on thyroid hormone homeostasis may differ between sexes.

中文翻译：

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偏远阿拉斯加原住民群体中全氟烷基物质的暴露及其与血清甲状腺激素的关系。


众所周知，全氟烷基物质（PFAS）会在北极的传统食用动物中积累，北极土著人民可能会通过食用自给自足的动物而接触到这种物质。 PFAS 被怀疑会破坏人类甲状腺激素的稳态。本研究的目的是评估偏远阿拉斯加原住民群体中血清 PFAS 与甲状腺功能之间的关系。血清样本采集自阿拉斯加圣劳伦斯岛的 85 名个体。对血清样品中 13 种 PFAS 以及游离和总甲状腺素 (T4)、游离和总三碘甲状腺原氨酸 (T3) 以及促甲状腺素 (TSH) 的浓度进行了定量。使用与广义估计方程拟合的多元线性回归来评估 PFAS 和甲状腺激素的循环浓度之间的关系。单独建模时，包括全氟辛酸 (PFOA) 和全氟壬酸 (PFNA) 在内的多种 PFAS 与 TSH 浓度呈正相关。在 PFAS* 性别交互项模型中，PFOS 和 PFNA 与游离 T3 显着相关，PFNA 与总 T3 显着相关；这些关联表明，男性中存在负关联，而女性中存在正关联。 PFAS 与游离或总 T4 浓度没有显着相关。血清 PFAS 与偏远阿拉斯加原住民群体中循环甲状腺激素浓度相关。 PFAS 暴露对甲状腺激素稳态的影响可能因性别而异。