Advancing Flow Chemistry Portability: A Simplified Approach to Scaling Up Flow Chemistry,Organic Process Research & Development

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Advancing Flow Chemistry Portability: A Simplified Approach to Scaling Up Flow Chemistry
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-06-27 00:00:00 , DOI: 10.1021/acs.oprd.8b00063
François Lévesque ₁ , Nicholas J. Rogus ₁ , Glenn Spencer ₁ , Plamen Grigorov ₁ , Jonathan P. McMullen ₁ , David A. Thaisrivongs ₁ , Ian W. Davies ₁ , John R. Naber ₁

Affiliation

We report mixing characterization of five lab-scale and eight production-scale static mixers using a modified fourth Bourne reaction. An efficient inline method relying on UV–vis spectroscopy was developed to streamline analysis of the product distribution. As a result of these studies, we have designed, 3D-printed, and characterized a stainless steel static mixer. This approach enabled the evaluation of different configurations and ensured efficient scale-up across development and commercial facilities that should allow for enhanced portability of mixing-sensitive processes.

中文翻译：

推进流动化学的可移植性：简化流动化学的简化方法

我们报告了使用改进的第四波恩反应对五台实验室规模和八台生产规模的静态混合器进行混合的特性。开发了一种依靠紫外可见光谱的有效在线方法来简化产品分布的分析。这些研究的结果是，我们设计，3D打印并表征了不锈钢静态混合器。这种方法可以评估不同的配置，并确保在开发和商业设施之间有效地扩大规模，这应该可以增强混合敏感过程的可移植性。

更新日期：2018-06-27

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