Fluidized bed spray agglomeration is used in the industry to increase the particle size and to improve several properties, for example, bulk density, flowability, and dissolution behavior of particulate products. Usually, a binder liquid is sprayed on a particle bed. If amorphous materials are used, spraying of pure water may cause agglomeration due to glass transition at wet spots on the particle surface. As no process models covering binder‐less spray agglomeration currently exist, a model based on a Monte Carlo method is presented. In this method, the process is described by events and processes on the single particle scale. Additionally, agglomeration experiments in a lab‐scale fluidized bed using three different maltodextrins are presented. For each experiment, a simulation was performed. The simulation results are compared with the obtained experimental data. © 2018 American Institute of Chemical Engineers AIChE J, 64: 3582–3594, 2018

中文翻译：

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流化床中无粘结剂喷雾团聚的蒙特卡洛模型

工业上使用流化床喷雾附聚来增加粒度并改善若干性质，例如，堆积密度，流动性和颗粒产物的溶解行为。通常，将粘合剂液体喷雾在颗粒床上。如果使用无定形材料，纯净水的喷洒可能会由于颗粒表面湿点处的玻璃化转变而导致结块。由于目前尚无涵盖无粘结剂喷雾团聚的工艺模型，因此提出了一种基于蒙特卡洛方法的模型。在这种方法中，该过程由事件和单个粒子尺度上的过程来描述。此外，还介绍了在实验室规模的流化床中使用三种不同麦芽糖糊精进行的团聚实验。对于每个实验，都进行了模拟。将仿真结果与获得的实验数据进行比较。©2018美国化学工程师学会AIChE J，64：3582–3594，2018