Protein citrullation, catalyzed by protein arginine deiminases (PADs), is a highly consequential and tightly regulated post‐translational modification. Aberrantly activated and overexpressed PADs are associated with several human diseases. Yet, what precise roles they play in specific cell types are not fully understood. Herein, a new development of clickable probes for functional profiling of cellular PADs at the proteome level is highlighted.

中文翻译：

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蛋白质精氨酸脱亚氨酶的高效细胞穿透探针，用于功能蛋白质组学

蛋白质精氨酸脱亚氨酶（PADs）催化的蛋白质瓜氨酸化是一种高度必然的结果，且翻译后修饰受到严格的调控。异常激活和过度表达的PAD与几种人类疾病有关。然而，它们在特定细胞类型中所起的确切作用尚不完全清楚。在本文中，重点介绍了在蛋白质组水平上用于细胞PAD功能分析的可点击探针的新开发。