An Efficient Chan-Lam S-Arylation of Arylthioureas with Aryl Boronic Acids,European Journal of Organic Chemistry

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An Efficient Chan-Lam S-Arylation of Arylthioureas with Aryl Boronic Acids
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-17 , DOI: 10.1002/ejoc.201800892
Xing Liu ₁ , Shi-Bo Zhang ₁ , Hui Zhu ₁ , Yu Cheng ₁ , Han-Ying Peng ₁ , Zhi-Bing Dong _{1,

2}

Affiliation

A convenient and efficient protocol has been developed for the preparation of aryl-isothioureas based on the Chan-Lam C-S coupling reaction. The desired aryl-isothioureas were synthesized in good yields (up to 95%) in the presence of Cu(OAc)(2)H2O as catalyst and bipyridine as ligand. A variety of functional groups on the aryl-thiourea and arylboronic acid reagents are tolerated. The method features mild reaction conditions and good yields, thereby illustrating its practical synthetic value in organic synthesis.

中文翻译：

芳基硫脲与芳基硼酸的有效 Chan-Lam S-芳基化

基于 Chan-Lam CS 耦合反应的芳基异硫脲的制备开发了一种方便有效的协议。在作为催化剂的 Cu(OAc)(2)H2O 和作为配体的联吡啶存在下，以良好的收率（高达 95%）合成了所需的芳基异硫脲。可以耐受芳基硫脲和芳基硼酸试剂上的各种官能团。该方法反应条件温和，收率好，说明了其在有机合成中的实用合成价值。

更新日期：2018-08-17

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