4-n-butyl resorcinol (4-nBR) is a highly effective tyrosinase inhibitor, and can be used in cosmetic product for depigmentation purpose. Its efficacy correlates with 4-nBR that absorbed by skin. In this study, skin distribution of 4-nBR within either human or pig skin ex vivo was studied and compared by three independent laboratories. Good agreement was observed in each compartment considering usual inter-lab variability. This study supports the use of pig skin as an alternative source of skin when the availability of human skin is a limiting factor.

中文翻译：

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体外猪和人皮肤中4-正丁基间苯二酚皮肤分布的实验室间研究

4-正丁基间苯二酚（4-nBR）是一种高效的酪氨酸酶抑制剂，可用于化妆品中的脱色用途。它的功效与皮肤吸收的4-nBR有关。在这项研究中，研究了4-nBR在人或猪体内离体皮肤的分布情况，并通过三个独立的实验室进行了比较。考虑到通常的实验室间变异性，在每个隔室中观察到良好的一致性。当人类皮肤的可用性是一个限制因素时，这项研究支持使用猪皮肤作为皮肤的替代来源。