Chronic stress has been extensively linked to disturbances in glutamatergic signalling. Emerging from this field of research is a considerable number of studies identifying the ability of purines at the pre-, post-, and peri-synaptic levels to tune glutamatergic neurotransmission. While the evidence describing purinergic control of glutamate has continued to grow, there has been relatively little attention given to how chronic stress modulates purinergic functions. The available research on this topic has demonstrated that chronic stress can not only disturb purinergic receptors involved in the regulation of glutamate neurotransmission, but also perturb glial-dependent purinergic signalling. This review will provide a detailed examining of the complex literature relating to glutamatergic-purinergic interactions with a focus on both neuronal and glial contributions. Once these detailed interactions have been described and contextualised, we will integrate recent findings from the field of stress research.

慢性应激已被广泛地与谷氨酸能信号传导的紊乱联系在一起。来自该研究领域的大量研究确定了嘌呤在突触前，突触后和突触周围水平调节谷氨酸能神经传递的能力。虽然描述谷氨酸的嘌呤能控制的证据继续增长，但是对慢性应激如何调节嘌呤能的功能的关注相对较少。关于该主题的现有研究表明，慢性应激不仅会干扰与调节谷氨酸神经传递有关的嘌呤能受体，而且还会干扰胶质依赖的嘌呤能信号传导。这篇综述将详细探讨与谷氨酰胺-嘌呤能相互作用有关的复杂文献，重点是神经元和神经胶质的贡献。一旦对这些详细的相互作用进行了描述并根据具体情况进行了介绍，我们将整合压力研究领域的最新发现。