Magnetic nanoparticles(MNPs) with excellent monodispersity, colloidal stability and biocompatibility are important for the fabrication of magnetic targeted drug delivery system. In this study, magnetic lipid microcapsules (MLMs) containing lipid-coated MNPs was fabricated. 5-(6)-carboxyfluorescein (CF) release from MLMs triggered through thermal activation of MNPs were investigated in detail upon application of an alternating magnetic field (AMF). The experimental results revealed that coating lipid on MNPs effectively reduced the MNPs aggregation, enhanced the dispersion, stability and biocompatibility but did not affect their heat transfer. This new drug delivery system holds a great potential on cancer treatment.

具有优异的单分散性，胶体稳定性和生物相容性的磁性纳米颗粒（MNP）对于磁性靶向药物输送系统的制造至关重要。在这项研究中，磁性脂质微胶囊（MLMs）包含脂质涂层的MNPs。在施加交变磁场（AMF）后，对通过MNP的热激活触发的MLM中的5-（6）-羧基荧光素（CF）释放进行了详细研究。实验结果表明，在MNPs上涂覆脂质可以有效地减少MNPs的聚集，增强其分散性，稳定性和生物相容性，但不影响其传热。这种新的药物输送系统在癌症治疗方面具有巨大的潜力。