Unraveling the rewired network

Unraveling the rewired network, Published online: 25 June 2018; doi:10.1038/s41589-018-0083-7

Adaptive survival signaling can promote resistance to individual kinase inhibitors. A new study used a pathway-based approach to characterize shared kinome-wide rewiring mechanisms across multiple kinase inhibitors and developed rational drug-combination approaches that target cross-talk between two signaling pathways.

中文翻译：

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拆解重新连接的网络。

拆解有线网络

拆解有线网络，在线发布：2018年6月25日; doi：10.1038 / s41589-018-0083-7

适应性生存信号转导可以增强对单个激酶抑制剂的耐药性。一项新的研究使用了一种基于途径的方法来表征多种激酶抑制剂之间共享的全基因组范围内的重新接线机制，并开发了针对两种信号途径之间串扰的合理药物组合方法。