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Bioinactivation FE: A free web application for modelling isothermal and dynamic microbial inactivation.
Food Research International ( IF 7.0 ) Pub Date : 2018-06-25 , DOI: 10.1016/j.foodres.2018.06.057
Alberto Garre 1 , Marta Clemente-Carazo 1 , Pablo S Fernández 1 , Roland Lindqvist 2 , Jose A Egea 3
Affiliation  

Mathematical models developed in predictive microbiology are nowadays an essential tool for food scientists and researchers. However, advanced knowledge of scientific programming and mathematical modelling are often required in order to use them, especially in cases of modelling of dynamic and/or non-linear processes. This may be an obstacle for food scientists without such skills. Scientific software can help making these tools more accessible for scientists lacking a deep mathematical or computing background. Recently, the R package bioinactivation was published, including functions (model fitting and predictions) for modelling microbial inactivation under isothermal or dynamic conditions. It was uploaded to the Comprehensive R Archive Network (CRAN), but users need basic R programming knowledge in order to use it. Therefore, it was accompanied by Bioinactivation SE, a user-friendly web application including selected functions in the software for users without a programming background. In this work, a new web application, Bioinactivation FE, is presented. It is an extension of Bioinactivation SE which includes an interface to every function in the bioinactivation package: model fitting of isothermal and non-isothermal experiments, and generation of survivor curves and prediction intervals. Moreover, it includes several improvements in the user interface based on the users' feedback. The capabilities of the software are demonstrated through two case studies using data published in the scientific literature. In the first case study, the response of Escherichia coli to isothermal and non-isothermal treatments is compared, illustrating the presence of an induced thermal resistance. In the second, the effect of nanoemulsified d-limonene on the thermal resistance of Salmonella Senftenberg is quantified.

中文翻译:

生物灭活FE:用于模拟等温和动态微生物灭活的免费Web应用程序。

如今,预测微生物学中开发的数学模型已成为食品科学家和研究人员的必不可少的工具。但是,为了使用它们,常常需要科学编程和数学建模的高级知识,尤其是在对动态和/或非线性过程进行建模的情况下。对于没有这种技能的食品科学家来说,这可能是一个障碍。科学软件可以帮助缺乏深厚数学或计算机背景的科学家更容易使用这些工具。最近,已发布了R包生物灭活剂,包括用于在等温或动态条件下对微生物灭活进行建模的功能(模型拟合和预测)。它已上载到综合R存档网络(CRAN),但是用户需要基本的R编程知识才能使用它。所以,它附带了Bioinactivation SE,它是一个用户友好的Web应用程序,其中包括软件的部分功能,适合没有编程背景的用户。在这项工作中,提出了一个新的Web应用程序Bioinactivation FE。它是生物灭活SE的扩展,其中包括生物灭活程序包中每个功能的接口:等温和非等温实验的模型拟合,以及幸存曲线和预测间隔的生成。此外,它还基于用户的反馈对用户界面进行了一些改进。该软件的功能通过使用科学文献中公布的数据的两个案例研究得到证明。在第一个案例研究中,比较了大肠杆菌对等温和非等温处理的反应,说明了感应热阻的存在。第二,量化了纳米乳化的d-柠檬烯对沙门氏菌Senftenberg耐热性的影响。
更新日期:2018-06-25
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