A Platinum(II) Complex of Heptamethine Cyanine for Photoenhanced Cytotoxicity and Cellular Imaging in Near‐IR Light,Angewandte Chemie International Edition

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A Platinum(II) Complex of Heptamethine Cyanine for Photoenhanced Cytotoxicity and Cellular Imaging in Near‐IR Light
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-07-16 , DOI: 10.1002/anie.201806911
Koushambi Mitra _{1,

2} , Charles E Lyons ₂ , Matthew C T Hartman _{1,

2}

Affiliation

Controlled generation of cytotoxic agents with near‐IR light is a current focus of photoactivated cancer therapy, including that involving cytotoxic platinum species. A heptamethine cyanine scaffolded Pt^II complex, IR797‐Platin exhibits unprecedented Pt−O bond scission and enhancement in DNA platination in near‐IR light. This complex also displayed significant singlet oxygen quantum yield thereby qualifying as a near‐IR photodynamic therapeutic agent. The complex showed 30–60 fold enhancement of cytotoxicity in near‐IR light in various cancer cell lines. The cellular imaging properties were also leveraged to observe its significant co‐localization in cytoplasmic organelles. This is the first demonstration of a near‐IR light‐initiated therapy involving the cytotoxic effects of both active cisplatin and singlet oxygen.

中文翻译：

用于近红外光增强细胞毒性和细胞成像的七次甲基花青铂 (II) 络合物

用近红外光控制产生细胞毒性剂是光激活癌症治疗的当前焦点，包括涉及细胞毒性铂类的治疗。 IR797-Platin 是一种七次甲基花青支架 Pt ^II复合物，在近红外光下表现出前所未有的 Pt-O 键断裂和 DNA 铂化增强。该复合物还表现出显着的单线态氧量子产率，因此有资格作为近红外光动力治疗剂。该复合物在近红外光下对多种癌细胞系的细胞毒性增强了 30-60 倍。细胞成像特性也被用来观察其在细胞质细胞器中的显着共定位。这是近红外光引发疗法的首次演示，涉及活性顺铂和单线态氧的细胞毒性作用。

更新日期：2018-07-16

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