Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells,Advanced Science

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Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells
Advanced Science ( IF 14.3 ) Pub Date : 2018-06-25 , DOI: 10.1002/advs.201700859
Xian Wu ₁ , Yanhong Zhu ₁ , Wei Huang ₁ , Jingqiu Li ₁ , Bixiang Zhang ₂ , Zifu Li _{1,

3,

4} , Xiangliang Yang ₁

Affiliation

Hypoxia is a fundamental hallmark of solid tumors and helps contribute to chemotherapy resistance. Hyperbaric oxygen (HBO) therapy can overcome tumor hypoxia and promote chemotherapy antitumor efficacy; however, the simultaneous administration of some conventional chemotherapies, including doxorubicin (DOX), with HBO is considered an absolute contraindication. Here, DOX‐loaded liposome (Doxil) is coadministered with HBO to assess the safety and efficacy of this combination treatment. By overcoming tumor hypoxia, HBO not only improves Doxil tumor penetration by decreasing the collagen deposition but also sensitizes tumor cells to Doxil. As a result, the combination treatment synergistically inhibits H22 tumor growth, with a tumor inhibition rate of 91.5%. The combination of HBO with Doxil shows neither extra side effects nor promotion of tumor metastasis. These results collectively reveal that the combination of HBO with Doxil is an effective and safe treatment modality. As both HBO and Doxil are routinely used, their combination could quickly translate to clinical trials for patients with hypoxic solid tumors.

中文翻译：

高压氧通过促进肿瘤渗透并使癌细胞敏感来增强 Doxil 的抗肿瘤功效

缺氧是实体瘤的基本标志，有助于增强化疗耐药性。高压氧（HBO）治疗可以克服肿瘤缺氧，促进化疗抗肿瘤疗效；然而，一些常规化疗药物（包括阿霉素 (DOX)）与 HBO 同时给药被认为是绝对禁忌症。在这里，负载 DOX 的脂质体 (Doxil) 与 HBO 共同给药，以评估这种联合治疗的安全性和有效性。通过克服肿瘤缺氧，HBO不仅通过减少胶原蛋白沉积来提高Doxil肿瘤渗透性，而且还使肿瘤细胞对Doxil敏感。结果，联合治疗协同抑制H22肿瘤生长，肿瘤抑制率为91.5%。 HBO与Doxil的组合既没有显示出额外的副作用，也没有显示出促进肿瘤转移。这些结果共同表明 HBO 与 Doxil 的组合是一种有效且安全的治疗方式。由于 HBO 和 Doxil 都是常规使用，因此它们的组合可以快速转化为针对缺氧实体瘤患者的临床试验。

更新日期：2018-06-25

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