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Bioinspired Mineral–Organic Bioresorbable Bone Adhesive
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-06-25 , DOI: 10.1002/adhm.201800467
Alina Kirillova 1 , Cambre Kelly 1 , Natalia von Windheim 1 , Ken Gall 1
Affiliation  

Bioresorbable bone adhesives have potential to revolutionize the clinical treatment of the human skeletal system, ranging from the fixation and osteointegration of permanent implants to the direct healing and fusion of bones without permanent fixation hardware. Despite an unmet need, there are currently no bone adhesives in clinical use that provide a strong enough bond to wet bone while possessing good osteointegration and bioresorbability. Inspired by the sandcastle worm that creates a protective tubular shell around its body using a proteinaceous adhesive, a novel bone adhesive is introduced, based on tetracalcium phosphate and phosphoserine, that cures in minutes in an aqueous environment and provides high bone‐to‐bone adhesive strength. The new material is measured to be 10 times more adhesive than bioresorbable calcium phosphate cement and 7.5 times more adhesive than non‐resorbable poly(methyl methacrylate) bone cement, both of which are standard of care in the clinic today. The bone adhesive also demonstrates chemical adhesion to titanium approximately twice that of its adhesion to bone, unlocking the potential for adherence to metallic implants during surrounding bony incorporation. Finally, the bone adhesive is shown to demonstrate osteointegration and bioresorbability over a 52‐week period in a critically sized distal femur defect in rabbits.

中文翻译:

受生物启发的矿物-有机生物可吸收骨粘合剂

生物可吸收性骨粘合剂具有革新人类骨骼系统临床治疗的潜力,从永久性植入物的固定和骨整合到没有永久性固定硬件的骨骼的直接愈合和融合。尽管需求未得到满足,但是目前在临床上没有骨粘合剂能够提供与湿骨足够强的结合力,同时具有良好的骨整合性和生物吸收性。受沙堡蠕虫的启发,蠕虫使用蛋白质粘合剂在其周围形成保护性管状外壳,并引入了一种基于磷酸四钙和磷酸丝氨酸的新型骨粘合剂,​​该粘合剂在水性环境中可在数分钟内固化,并提供高骨-骨粘合剂力量。经测量,这种新材料的粘合力是可生物吸收的磷酸钙水泥的粘合力的10倍和7倍。胶粘剂比不可吸收的聚(甲基丙烯酸甲酯)骨水泥高5倍,这两种胶粘剂都是当今临床上的标准护理。骨粘合剂还显示出对钛的化学粘附力,大约是其对骨骼的粘附力的两倍,从而释放了在周围骨结合过程中对金属植入物的粘附潜能。最后,骨黏结剂在严重的兔股骨远端缺损中,在52周内显示出骨整合和生物吸收性。在周围的骨结合过程中释放了粘附到金属植入物上的潜力。最后,骨黏结剂在严重的兔股骨远端缺损中,在52周内显示出骨整合和生物吸收性。在周围的骨结合过程中释放了粘附到金属植入物上的潜力。最后,骨黏结剂在严重的兔股骨远端缺损中,在52周内显示出骨整合和生物吸收性。
更新日期:2018-06-25
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