Recent advances in nanomedicine‐based theranostic platforms have catalyzed the generation of new theranostic modalities for pathological abnormalities, such as cancer. Mesoporous silica–based nanomedicines, which feature unique physicochemical properties and specific applicability, are extensively explored for numerous oncological applications. Due to the well‐defined morphology, specific surface area, and pore volume, mesoporous silica nanoparticle (MSN)‐based theranostic platforms have provided unprecedented opportunities for the development of next‐generation cancer nanomedicine. However, current understanding on the underlying mechanisms of how these feasible theranostic platforms interact with exogenous/endogenous triggers and how this unique responsiveness for optimized cancer therapy can be taken advantage of is still preliminary. In this progress report, efforts are made to give a comprehensive overview of the development of MSN‐based “smart” theranostic platforms, from exogenous physical irradiation–triggered platforms for localized therapy to endogenous biological stimulus–triggered platforms for tumor microenvironment responsiveness. It is highly expected that these elaborately fabricated MSN‐based nanoformulations will play an indispensable role in the efficient cancer therapy based on their high therapeutic outcome and reduced side effects.

中文翻译：

---

外源/内源触发的中孔二氧化硅癌纳米医学

基于纳米医学的治疗学平台的最新进展催化了诸如癌症等病理异常的新治疗学方法的产生。具有独特的理化性质和特定适用性的中孔二氧化硅基纳米药物已被广泛用于众多肿瘤学领域。由于形态，比表面积和孔体积的明确定义，基于介孔二氧化硅纳米颗粒（MSN）的治疗学平台为下一代癌症纳米药物的开发提供了前所未有的机会。但是，目前对这些可行的治疗方法平台如何与外源/内源性触发因素相互作用以及如何利用这种独特的反应性来优化癌症治疗的潜在机制的初步了解仍是初步的。在此进展报告中，我们努力全面概述了基于MSN的“智能”治疗方法平台的开发，从用于局部治疗的外源物理辐射触发平台到用于肿瘤微环境响应的内源性生物刺激触发平台。高度期望这些精心制作的基于MSN的纳米制剂将基于其高治疗效果和减少的副作用，在有效的癌症治疗中发挥不可或缺的作用。