Mini Review of TiO2‐Based Multifunctional Nanocomposites for Near‐Infrared Light–Responsive Phototherapy,Advanced Healthcare Materials

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Mini Review of TiO2‐Based Multifunctional Nanocomposites for Near‐Infrared Light–Responsive Phototherapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-06-25 , DOI: 10.1002/adhm.201800351
Meifang Wang _{1,

2} , Zhiyao Hou ₁ , Abdulaziz A. Al Kheraif ₃ , Bengang Xing ₄ , Jun Lin _{1,

3}

Affiliation

Phototherapy with the properties of specific spatial/temporal selectivity and minimal invasiveness has been acknowledged as one of the most promising cancer therapy types. Among all the photoactive substance for phototherapy, titanium dioxide (TiO₂) nanomaterials are paid more and more attention due to their outstanding photocatalytic properties, prominent biocompatibility, and excellent chemical stability. However, the wide bandgap (3.0–3.2 eV) of TiO₂ limits its absorption only to the ultraviolet (UV) light region. For a long time, UV light–stimulated TiO₂ was applied in the phototherapy researches of tumors located in the skin layer, while it is unsatisfactory for most deep‐tissue tumors. Due to the maximum penetration into tissue existing in the near‐infrared (NIR) region, how to use NIR light to trigger photochemical reaction of TiO₂ remains a big challenge. In this review, two strategies to develop and construct NIR‐triggered TiO₂‐based nanocomposites (NCs) for phototherapy are summarized, and the relevant mechanism and background knowledge of TiO₂‐based phototherapy are also given in order to better understand the application value and current situation of TiO₂ in phototherapy. Finally, the challenges and research directions of TiO₂ in the future clinic phototherapy application are also discussed.

中文翻译：

基于TiO2的多功能纳米复合材料的近红外光响应光疗法的迷你回顾

具有特定的时空选择性和微创性的光疗法已被认为是最有前途的癌症疗法之一。在用于光疗的所有光活性物质中，二氧化钛（TiO ₂）纳米材料因其出色的光催化性能，突出的生物相容性和出色的化学稳定性而受到越来越多的关注。但是，TiO ₂的宽带隙（3.0–3.2 eV）限制了它仅对紫外（UV）光区域的吸收。长期以来，紫外线刺激的TiO ₂该技术被用于皮肤表层肿瘤的光疗研究，但对于大多数深层组织肿瘤而言却不尽人意。由于最大程度地渗透到近红外（NIR）区域中存在的组织中，如何使用近红外光引发TiO _2的光化学反应仍然是一个巨大的挑战。本文综述了开发和构建用于光疗的近红外激发的TiO ₂基纳米复合材料（NCs）的两种策略，并给出了基于TiO ₂的光疗的相关机理和背景知识，以更好地理解其应用价值。和光疗中TiO _2的现状。最后，TiO ₂的挑战和研究方向在未来的临床光疗应用中也进行了讨论。

更新日期：2018-06-25

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