Novel Mechanism of Fatty Acid Sensing in Enteroendocrine Cells: Specific Structures in Oxo‐Fatty Acids Produced by Gut Bacteria Are Responsible for CCK Secretion in STC‐1 Cells via GPR40,Molecular Nutrition & Food Research

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Novel Mechanism of Fatty Acid Sensing in Enteroendocrine Cells: Specific Structures in Oxo‐Fatty Acids Produced by Gut Bacteria Are Responsible for CCK Secretion in STC‐1 Cells via GPR40
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-07-25 , DOI: 10.1002/mnfr.201800146
Tohru Hira ₁ , Shono Ogasawara ₂ , Asuka Yahagi ₂ , Minami Kamachi ₂ , Jiaxin Li ₃ , Saki Nishimura ₄ , Masayoshi Sakaino ₄ , Takatoshi Yamashita ₄ , Shigenobu Kishino ₅ , Jun Ogawa ₅ , Hiroshi Hara ₁

Affiliation

The secretion of gut hormones, such as cholecystokinin (CCK) is stimulated by fatty acids. Although a chain length–dependent mechanism has been proposed, other structural relationships to releasing activity remain unclear. We aimed to elucidate specific structures in fatty acids that are responsible for their CCK‐releasing activity, and related sensing mechanisms in enteroendocrine cells.

中文翻译：

肠内分泌细胞中脂肪酸传感的新机制：肠道细菌产生的含氧脂肪酸中的特定结构通过GPR40负责STC-1细胞中CCK的分泌。

脂肪酸刺激肠内激素（例如胆囊收缩素（CCK））的分泌。尽管已经提出了依赖链长的机制，但与释放活性的其他结构关系仍不清楚。我们旨在阐明负责其CCK释放活性的脂肪酸的特定结构，以及肠内分泌细胞的相关传感机制。

更新日期：2018-07-25

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