Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming,Molecular Nutrition & Food Research

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Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-07-31 , DOI: 10.1002/mnfr.201800263
Evangelina Capobianco _{1,

2} , Dalmiro Gomez Ribot _{1,

2} , Daiana Fornes _{1,

2} , Theresa L. Powell _{3,

4} , Cecilia Levieux _{1,

2} , Thomas Jansson ₄ , Alicia Jawerbaum _{1,

2}

Affiliation

Offspring from rats with mild diabetes develop gestational diabetes mellitus (GDM). We tested the hypothesis that an olive oil‐supplemented diet attenuates placental oxidative stress/inflammation, activation of mTOR signaling, and inhibition of peroxisome proliferator‐activated receptor γ (PPARγ) and fetal overgrowth in GDM offspring from mild diabetic rats.

中文翻译：

富含橄榄油的饮食可减轻宫内程序设计诱发的妊娠期糖尿病大鼠的胎盘功能障碍。

患有轻度糖尿病的大鼠的后代会发育成妊娠糖尿病（GDM）。我们检验了以下假设：在轻度糖尿病大鼠的GDM子代中，以橄榄油为食的饮食可减轻胎盘氧化应激/炎症，mTOR信号的激活以及过氧化物酶体增殖物激活受体γ（PPARγ）的抑制和胎儿过度生长。

更新日期：2018-07-31

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