当前位置：
X-MOL 学术
›
Anal. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
A Chiral Organic Field-Effect Transistor with a Cyclodextrin Modulated Copper Hexadecafluorophthalocyanine Semiconductive Layer as the Sensing Unit
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-06-26 00:00:00 , DOI: 10.1021/acs.analchem.8b01806 Yuwei Sun 1 , Yong Wang 1 , Yifan Wu 1 , Xuepeng Wang 1 , Xianggao Li 1 , Shirong Wang 1 , Yin Xiao 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-06-26 00:00:00 , DOI: 10.1021/acs.analchem.8b01806 Yuwei Sun 1 , Yong Wang 1 , Yifan Wu 1 , Xuepeng Wang 1 , Xianggao Li 1 , Shirong Wang 1 , Yin Xiao 1
Affiliation
|
This work reported the construction of a chiral sensor based on an organic field-effect transistor to probe the subtle change of weak interactions in the chiral discrimination process, with the ability to achieve fast, sensitive, and quantitative real-time chiral analysis for various racemic pairs, where a β-cyclodextrin (β-CD) sensitized copper hexadecafluorophthalocyanine (F16CuPc) semiconductive layer was employed as the sensing unit. Physical adsorptive assembly of β-CD on the semiconductive layer guarantees the impressive field-effect-amplified chiral sensitivity. The enantiomer induced aggregation pattern diversification of the sensing layer resulted in enhanced or weakened surface-dipole interactions to various degrees and hence brought about the drain current fluctuation. A fast and real-time detection of the enantiomer pairs in aqueous solution at 10–9 M was achieved. This chiral organic field-effect transistor (COFET) afforded reliable ability for quantitative determination of the pure isomer content in enantiomer pairs and was further proven to have great potential for the resolution of “real-world” pharmaceutical drugs.
中文翻译：
以环糊精调制的六氟铜酞菁铜半导电层为传感单元的手性有机场效应晶体管
这项工作报告了一种基于有机场效应晶体管的手性传感器的构建，以探测手性识别过程中弱相互作用的细微变化，并能够对各种外消旋体进行快速，灵敏和定量的实时手性分析。对，其中β-环糊精（β-CD）敏化了十六氟铜酞菁铜（F 16将CuPc）半导体层用作感测单元。β-CD在半导体层上的物理吸附组装确保了令人印象深刻的场效应放大手性灵敏度。对映异构体引起的传感层聚集图案的多样化导致表面-偶极相互作用的增强或减弱到不同程度，并因此引起了漏极电流的波动。快速，实时检测水溶液中10–9 M的对映体对。这种手性有机场效应晶体管（COFET）为定量测定对映异构体对中的纯异构体含量提供了可靠的能力，并且进一步证明具有解决“现实世界”药物的巨大潜力。
更新日期：2018-06-26
中文翻译：
以环糊精调制的六氟铜酞菁铜半导电层为传感单元的手性有机场效应晶体管
这项工作报告了一种基于有机场效应晶体管的手性传感器的构建，以探测手性识别过程中弱相互作用的细微变化，并能够对各种外消旋体进行快速，灵敏和定量的实时手性分析。对，其中β-环糊精（β-CD）敏化了十六氟铜酞菁铜（F 16将CuPc）半导体层用作感测单元。β-CD在半导体层上的物理吸附组装确保了令人印象深刻的场效应放大手性灵敏度。对映异构体引起的传感层聚集图案的多样化导致表面-偶极相互作用的增强或减弱到不同程度，并因此引起了漏极电流的波动。快速，实时检测水溶液中10–9 M的对映体对。这种手性有机场效应晶体管（COFET）为定量测定对映异构体对中的纯异构体含量提供了可靠的能力，并且进一步证明具有解决“现实世界”药物的巨大潜力。
京公网安备 11010802027423号