Dysregulation of cell metabolism and redox balance is implicated in the pathogenesis and progression of cancer and autoimmune diseases. Because the cell proliferation and apoptotic regulatory pathways are interconnected with metabolic and redox signalling pathways, the current mono-target treatment is ineffective, and multi-drug resistance remains common. Complex diseases are often implicated in a network-based context of pathology; therefore, a new holistic intervention approach is required to block multi-crosstalk in such complicated circumstances. The use of therapeutic agents isolated from herbs to holistically modulate metabolism and redox state has been shown to relieve carcinoma growth and the inflammatory response in autoimmune disorders. Multiple clinically applied or novel herbal chemicals with metabolic and redox modulatory capacity as well as low toxicity have recently been identified. Moreover, new metabolic targets and mechanisms of drug action have been discovered, leading to the exploration of new pathways for drug repositioning, clinical biomarker spectra, clinical treatment strategies and drug development. Taken together with multiple supporting examples, the modulation of cell metabolism and the redox capacity using herbal chemicals is emerging as a new, alternative strategy for the holistic treatment of cancer and autoimmune disorders. In the future, the development of new diagnostic tools based on the detection of metabolic and redox biomarkers, reformulation of optimized herbal compositions using artificial intelligence, and the combination of herbs with mono-targeting drugs will reveal new potential for clinical application.

细胞代谢失调和氧化还原平衡与癌症和自身免疫性疾病的发病机理和进展有关。由于细胞增殖和凋亡调控通路与代谢和氧化还原信号通路相互关联，因此当前的单靶标治疗无效，并且多药耐药性仍然很普遍。复杂疾病通常与基于网络的病理环境有关。因此，在这种复杂的情况下，需要一种新的整体干预方法来阻止多重串扰。从草药中分离出的治疗剂可整体调节代谢和氧化还原状态，已显示可缓解癌症的生长以及自身免疫性疾病的炎症反应。最近已经确定了具有代谢和氧化还原调节能力以及低毒性的多种临床应用或新型草药。此外，已发现新的代谢靶标和药物作用机制，从而探索了药物重新定位，临床生物标志物光谱，临床治疗策略和药物开发的新途径。结合多个支持实例，使用草药化学物质调节细胞代谢和氧化还原能力正成为一种整体治疗癌症和自身免疫性疾病的新的替代策略。未来，将基于新陈代谢和氧化还原生物标记物的检测开发新的诊断工具，利用人工智能重新配制优化的草药成分，