The accurate treatment of tumors with the help of multimodality imaging is of great significance. Herein, a novel multifunctional probe combining active targeted fluorescent imaging (FL)/photoacoustic imaging (PA) and chemo-photothermal therapy for tumors has been designed. Targeting molecule folate (FA) modified graphene oxide (GO) was used to coat core–shell silver sulfide@mesoporous silica (QD@Si) while antitumoral doxorubicin (DOX) was loaded in mesoporous channels by electrostatic adhesion, and a delivery system (QD@Si-D/GO–FA) for active targeted dual-mode imaging and synergistic chemo-photothermal for tumors was successfully obtained. Experiments showed the cell survival rate was 76.3 ± 4.6% when the probe concentration reached 0.5 mg mL⁻¹, and demonstrated that the probe had good biocompatibility. In vivo and in vitro results indicated that this probe could be used for active targeted FL/PA for tumors with overexpressed FA receptors. The temperature of the tumor rose to 63.5 °C under laser irradiation, and the tumor could be killed more effectively after combination with chemotherapy, which was caused by exfoliation of GO from QD@Si-D/GO–FA after irradiation. These results showed that the probe had great potential for application in oncology and is expected to provide evidence for early diagnosis and treatment of tumors.

中文翻译：

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氧化石墨烯涂层核-壳硫化银@中氧化硅，用于针对性肿瘤的主动靶向双模式成像和化学光热协同治疗†

借助多模态成像准确地治疗肿瘤具有重要意义。在本文中，已经设计了一种新颖的多功能探针，该探针结合了针对肿瘤的主动靶向荧光成像（FL）/光声成像（PA）和化学光热疗法。用目标分子叶酸（FA）修饰的氧化石墨烯（GO）涂覆核-壳硫化银@中孔二氧化硅（QD @ Si），而抗肿瘤阿霉素（DOX）通过静电粘附和介孔系统装载在中孔通道中@ Si-D / GO–FA）已成功获得了用于肿瘤的主动靶向双模式成像和协同化学光热疗法。实验表明，当探针浓度达到0.5 mg mL ^-1时，细胞存活率为76.3±4.6％，证明该探针具有良好的生物相容性。体内和体外结果表明，该探针可用于具有过量表达FA受体的肿瘤的活性靶向FL / PA。在激光照射下，肿瘤的温度升至63.5°C，与化疗联合可以更有效地杀死肿瘤，这是由于照射后QD @ Si-D / GO-FA中GO的剥落所致。这些结果表明该探针在肿瘤学中具有巨大的应用潜力，有望为肿瘤的早期诊断和治疗提供证据。