Polyelectrolyte-based physical adhesive hydrogels with excellent mechanical properties for biomedical applications†,Journal of Materials Chemistry B

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Polyelectrolyte-based physical adhesive hydrogels with excellent mechanical properties for biomedical applications†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-25 00:00:00 , DOI: 10.1039/c8tb01160e
Wenxiang Li _{1,

2,

3,

4,

5} , Ruyan Feng _{4,

5,

6,

7,

8} , Rensheng Wang _{1,

2,

3,

4,

5} , Dan Li _{4,

5,

6,

7,

8} , Wenwen Jiang _{1,

2,

3,

4,

5} , Hanzhou Liu _{1,

2,

3,

4,

5} , Zhenzhong Guo _{8,

9,

10,

11,

12} , Michael J. Serpe _{13,

14,

15,

16} , Liang Hu _{1,

2,

3,

4,

5}

Affiliation

State Key Laboratory of Radiation Medicine and Protection
School for Radiological and Interdisciplinary Sciences (RAD-X)
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
Soochow University
Suzhou
College of Chemistry
Chemical Engineering and Materials Science
China
Hubei Province Key Laboratory of Occupational Hazard Identification and Control
Medical College
Wuhan University of Science and Technology
Wuhan
Department of Chemistry
University of Alberta
Edmonton
Canada

Physically crosslinked hydrogels were synthesized by copolymerization of acrylamide and acrylic acid monomers in the presence of cationic polyelectrolyte polydimethyldiallylammonium chloride. The fully physically crosslinked hydrogel showed good mechanical properties and good adhesion with a variety of substrates. These advantages can be attributed to the homogeneous distribution of crosslinking points due to hierarchical hydrogen bonds and electrostatic attractions in the hydrogel networks. Furthermore, these non-covalent bonds provided an effective pathway to dissipate energy. The mechanical properties of the hydrogels can be easily tuned by changing the chemical composition and ratio of monomers. We further showed that the transparent hydrogels were cytocompatible, and can be used for biomedical applications, including pH-triggered small molecule delivery and hydrogel-based hybrids for detecting doses of radiotherapy.

中文翻译：

基于聚电解质的物理粘合水凝胶，具有出色的机械性能，可用于生物医学应用†

物理交联的水凝胶是在阳离子聚电解质聚二甲基二烯丙基氯化铵存在下，通过丙烯酰胺和丙烯酸单体的共聚反应合成的。完全物理交联的水凝胶显示出良好的机械性能和与多种基材的良好粘合性。这些优点可以归因于由于水凝胶网络中的分层氢键和静电引力引起的交联点的均匀分布。此外，这些非共价键提供了耗散能量的有效途径。通过改变单体的化学组成和比例可以很容易地调节水凝胶的机械性能。我们进一步表明，透明水凝胶具有细胞相容性，可用于生物医学应用，

更新日期：2018-06-25

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