Self-assembling oxidized silk fibroin nanofibrils with controllable fractal dimensions†,Journal of Materials Chemistry B

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Self-assembling oxidized silk fibroin nanofibrils with controllable fractal dimensions†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-25 00:00:00 , DOI: 10.1039/c8tb00567b
Ke Zheng _{1,

2,

3,

4,

5} , Juan Yu _{1,

2,

3,

4,

5} , Wenwen Zhang _{1,

2,

3,

4,

5} , Xun Li _{1,

2,

3,

4,

5} , Yimin Fan _{1,

2,

3,

4,

5} , David L. Kaplan _{6,

7,

8,

9}

Affiliation

Negatively charged carboxyl groups were introduced onto silk fibroin by using sodium hypochlorite (NaClO) oxidation. The nanofibrillar structure of oxidized silk fibroin (OxSF) was investigated by thioflavin T fluorescence and TEM over time. The fractal dimension (D_f) value of 1.21 was obtained in 0.5 wt% OxSF with 2 mM NaClO oxidation (1.09 mM per g protein of carboxyl content), suggesting that the formation of individual nanofibrils was key during aggregation. Moreover, the fractal structure of the resulting nanofibrils was regulated by the charge distribution of OxSF. D_f values of 1.68, 1.48 and 1.24 were obtained in 0.2 wt% OxSF with 0.5, 1 and 2 mM NaClO in which the corresponding carboxyl content was 0.58, 0.75 and 1.09 mM per g protein, respectively. Nanoindentation measurements demonstrated reinforced hardness and modulus in OxSF–chitosan composite materials obtained by layer-by-layer deposition, with the highest average values of 1.23 ± 0.06 and 20.01 ± 1.64 GPa, respectively.

中文翻译：

分形尺寸可控的自组装氧化丝素蛋白纳米原纤维†

通过使用次氯酸钠（NaClO）氧化，将负电荷的羧基引入丝素蛋白上。随着时间的流逝，通过硫代黄素T荧光和TEM研究了氧化丝纤蛋白（OxSF）的纳米原纤维结构。在0.5 wt％OxSF中，经2 mM NaClO氧化（每g含羧基的蛋白质1.09 mM）获得的分形维数（D _f）值为1.21，这表明单个纳米原纤维的形成是聚集过程中的关键。而且，所得纳米原纤维的分形结构由OxSF的电荷分布调节。d _˚F在含有0.5、1和2 mM NaClO的0.2 wt％OxSF中获得1.68、1.48和1.24的值，其中每克蛋白质的相应羧基含量分别为0.58、0.75和1.09 mM。纳米压痕测量表明，通过逐层沉积获得的OxSF-壳聚糖复合材料具有增强的硬度和模量，最高平均值分别为1.23±0.06和20.01±1.64 GPa。

更新日期：2018-06-25

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