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Mitochondria-targeted half-sandwich rutheniumII diimine complexes: anticancer and antimetastasis via ROS-mediated signalling†
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2018-06-25 00:00:00 , DOI: 10.1039/c8qi00476e Zhishan Xu 1, 2, 3, 4, 5 , Deliang Kong 6, 7, 8, 9, 10 , Xiangdong He 6, 7, 8, 9, 10 , Lihua Guo 6, 7, 8, 9, 10 , Xingxing Ge 6, 7, 8, 9, 10 , Xicheng Liu 6, 7, 8, 9, 10 , Hairong Zhang 6, 7, 8, 9, 10 , Juanjuan Li 6, 7, 8, 9, 10 , Yuliang Yang 6, 7, 8, 9, 10 , Zhe Liu 6, 7, 8, 9, 10
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2018-06-25 00:00:00 , DOI: 10.1039/c8qi00476e Zhishan Xu 1, 2, 3, 4, 5 , Deliang Kong 6, 7, 8, 9, 10 , Xiangdong He 6, 7, 8, 9, 10 , Lihua Guo 6, 7, 8, 9, 10 , Xingxing Ge 6, 7, 8, 9, 10 , Xicheng Liu 6, 7, 8, 9, 10 , Hairong Zhang 6, 7, 8, 9, 10 , Juanjuan Li 6, 7, 8, 9, 10 , Yuliang Yang 6, 7, 8, 9, 10 , Zhe Liu 6, 7, 8, 9, 10
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Herein we present half-sandwich RuII diimine complexes that combine anticancer and antimetastasis activity into one molecule. Two half-sandwich RuII diimine complexes [(η6-p-cymene)Ru(N^N)Cl]PF6 have been synthesized and characterized. RuII complexes show antiproliferative activity against a wide range of cancer cell lines in vitro. In addition, they exhibit no cross-resistance with cisplatin. The complexes target mitochondria, damage mitochondrial integrity, and induce mitochondrial membrane permeabilization. Further studies show that the complexes can induce activation of caspase 3/PARP. Interestingly, the complexes finally lead to apoptosis and impede cell migration in cancer cells via ROS-mediated signalling.
中文翻译：
线粒体靶向的半三明治钌II二亚胺配合物：通过ROS介导的信号传导的抗癌和抗转移作用†
本文中，我们提出了将抗癌和抗转移活性结合到一个分子中的半三明治Ru II二亚胺复合物。两个半夹心钌II二亚胺络合物[（η 6 - p -cymene）的Ru（N ^ N）CL] PF 6已被合成和表征。Ru II复合物在体外对多种癌细胞系均具有抗增殖活性。另外，它们与顺铂没有交叉抗性。该复合物靶向线粒体，破坏线粒体完整性，并诱导线粒体膜通透。进一步的研究表明，该复合物可以诱导caspase 3 / PARP的激活。有趣的是，这些复合物最终导致细胞凋亡，并通过ROS介导的信号传导阻止癌细胞中的细胞迁移。
更新日期：2018-06-25
中文翻译：
线粒体靶向的半三明治钌II二亚胺配合物：通过ROS介导的信号传导的抗癌和抗转移作用†
本文中，我们提出了将抗癌和抗转移活性结合到一个分子中的半三明治Ru II二亚胺复合物。两个半夹心钌II二亚胺络合物[（η 6 - p -cymene）的Ru（N ^ N）CL] PF 6已被合成和表征。Ru II复合物在体外对多种癌细胞系均具有抗增殖活性。另外，它们与顺铂没有交叉抗性。该复合物靶向线粒体，破坏线粒体完整性，并诱导线粒体膜通透。进一步的研究表明，该复合物可以诱导caspase 3 / PARP的激活。有趣的是，这些复合物最终导致细胞凋亡，并通过ROS介导的信号传导阻止癌细胞中的细胞迁移。
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