Cell Alignment on Graphene–Amyloid Composites,Advanced Materials Interfaces

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Cell Alignment on Graphene–Amyloid Composites
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2018-06-25 , DOI: 10.1002/admi.201800621
Subhadeep Das _{1,

2} , Mukesh K. Kumawat ₂ , Srivastav Ranganathan ₂ , Rakesh Kumar ₂ , Jozef Adamcik ₃ , Pradeep Kadu ₂ , Ranjith Padinhateeri ₂ , Rohit Srivastava ₂ , Raffaele Mezzenga ₃ , Samir K. Maji ₂

Affiliation

Graphene‐based hybrid nanomaterials have been shown to have great potential in various biotechnology applications including enzyme sensing and bone tissue engineering. Harnessing the unique properties of graphene and material strength of amyloids, a graphene–amyloid composite film is developed that can self‐organize into periodic troughs and crests without the need of lithographic techniques or etching. The topographies generated by the film provide powerful modulators of contact and guidance to neural precursor cells, enabling efficient cellular polarization and differentiation. Using molecular dynamic simulations and high‐resolution atomic force microscopy, the amyloidogenicity and handedness of matured amyloid nanofibrils to the micropatterns generated on the dried film are also correlated. These insights provide principles for peptide designing for generation of micropatterned, cell adhesive conductive substrates for optimal cell alignment and differentiation.

中文翻译：

石墨烯-淀粉样蛋白复合材料的细胞排列

基于石墨烯的杂化纳米材料已被证明在包括酶感测和骨组织工程在内的各种生物技术应用中具有巨大的潜力。利用石墨烯的独特性质和淀粉状蛋白的材料强度，开发出了一种石墨烯-淀粉状蛋白复合膜，它可以自组织成周期性的波谷和波峰，而无需使用光刻技术或蚀刻。薄膜产生的形貌为神经前体细胞提供了强大的接触和引导调节剂，可实现高效的细胞极化和分化。使用分子动力学模拟和高分辨率原子力显微镜，还可以将淀粉样蛋白原纤维与成熟淀粉样纳米原纤维与干膜上产生的微图案的淀粉糊性和手性相关联。

更新日期：2018-06-25

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