The use of chitosan functionalized silica for benznidazole delivery in the treatment of neglected disease such as Chagas disease is one of the forms not yet explored, but with great potential for this therapy, as little is known about nanoformulations for the treatment of Chagas disease. In this work, we used chitosan-succinate covalently attached to the surface pore of MSNs to act as anchor for benznidazole as a delivery system. The samples were characterized structurally and chemically with multiple techniques. The applicability of functionalized MSNs as platforms for benznidazole delivery into T. cruzi parasites was assessed. The results demonstrate that the proposed system is a potential promising nanoplatform for drug and gene delivery targeting neglected diseases such as Chagas disease.

壳聚糖官能化二氧化硅用于苯甲硝唑递送以治疗被忽视的疾病（例如查加斯病）是一种尚未探索的形式，但是在这种治疗方法中具有很大的潜力，关于纳米制剂对查加斯病的治疗知之甚少。在这项工作中，我们使用共价附着于MSN表面孔的壳聚糖琥珀酸酯作为苯并硝唑的递送系统的锚点。使用多种技术对样品进行结构和化学表征。评估功能化的MSNs作为苯并硝唑递送至克鲁氏疟原虫寄生虫的平台的适用性。结果表明，提出的系统是潜在的有前途的纳米平台，可用于靶向被忽视的疾病（如恰加斯病）的药物和基因递送。