Aggregation-induced emission luminogen-based fluorescence detection of hypoxanthine: a probe for biomedical diagnosis of energy metabolism-related conditions†,Journal of Materials Chemistry B

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Aggregation-induced emission luminogen-based fluorescence detection of hypoxanthine: a probe for biomedical diagnosis of energy metabolism-related conditions†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-23 00:00:00 , DOI: 10.1039/c8tb00803e
Zhiling Zhang _{1,

2,

3,

4} , Ryan T. K. Kwok _{2,

3,

4,

5,

6} , Yong Yu _{1,

2,

3,

4} , Ben Zhong Tang _{2,

3,

4,

5,

6} , Ka Ming Ng _{1,

2,

3,

4}

Affiliation

Hypoxanthine is a well-known indicator of intracellular energy status that is associated with many pathological conditions. We report a fluorescent luminogen (TPE-HPro) with aggregation-induced emission (AIE) feature which, along with xanthine oxidase (XO), detects and quantifies hypoxanthine in a “turn-on” manner. The superior detection performance of this fluorometric assay indicates its great potential for biomedical diagnostics.

中文翻译：

黄嘌呤的聚集诱导的发射光基荧光检测：用于能量代谢相关疾病的生物医学诊断的探针†

次黄嘌呤是细胞内能量状态的众所周知指标，其与许多病理状况相关。我们报告了一种具有聚集诱导发射（AIE）功能的荧光发光剂（TPE-HPro），其与黄嘌呤氧化酶（XO）一起以“开启”方式检测和定量次黄嘌呤。这种荧光测定法的卓越检测性能表明其在生物医学诊断中的巨大潜力。

更新日期：2018-06-23

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