An efficient chiral catalyst procedure for the preparation of β-chiral ketone via the 1, 4-additions reaction of 2-en-ketone has been developed using enantiopure sulfoximines modified with functional groups as ligands. The carefully design and synthesized functional enantiopure sulfoximines could be used as linker. In this system the formation of new chiral centers occurs with the regioselective addition of the ethyl moiety at the terminal carbon of the 2-en-ketone. In addition, aromatic substituents in the substrate promote the addition reaction.

中文翻译：

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对映体磺胺嘧啶催化2-烯酮的1，4加成

通过使用经官能团修饰为配体的对映体纯亚砜亚胺，开发了一种通过2-烯酮的1，4-加成反应制备β-手性酮的有效手性催化剂程序。精心设计和合成的功能性对映体纯亚砜亚胺可用作连接体。在该系统中，新的手性中心的形成是通过在2-烯酮的末端碳上区域选择性地乙基部分的区域选择性加成而发生的。另外，底物中的芳族取代基促进加成反应。