Palladium‐Catalyzed Solvent‐Dependent Divergent Synthesis of Benzylformamides,Advanced Synthesis & Catalysis

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Palladium‐Catalyzed Solvent‐Dependent Divergent Synthesis of Benzylformamides
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-07-11 , DOI: 10.1002/adsc.201800674
Fu-Peng Wu ₁ , Jin-Bao Peng ₁ , Xinxin Qi ₁ , Jun Ying ₁ , Xiao-Feng Wu _{1,

2}

Affiliation

A palladium‐catalyzed carbonylative cascade procedure for the synthesis of benzylformamides from aryl halides has been developed. The properties of the solvent chosen play a decisive role on the selectivity of the outcomes. Non‐coordinative solvent facilitates the coordination and insertion of CO to the amino‐palladium intermediate which then provides the formamides products. While the use of coordinative solvent leads to the formation of amines. A series of functional groups, including ester, ketone, nitro and cyano, were well tolerated under our conditions. The corresponding benzylformamides products were prepared in moderate to good yields without further optimization.

中文翻译：

钯催化的苄基甲酰胺发散性合成

已经开发了一种钯催化的羰基级联方法，用于从芳基卤化物合成苄基甲酰胺。选择的溶剂的性质对结果的选择性起决定性作用。非配位溶剂有助于将CO配位并插入到氨基钯中间体中，然后再提供甲酰胺产品。同时使用配位溶剂会导致胺的形成。在我们的条件下，对包括酯，酮，硝基和氰基在内的一系列官能团具有很好的耐受性。相应的苄基甲酰胺产物以中等至良好的收率制备，无需进一步优化。

更新日期：2018-07-11

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