Enantioselective Construction of Vicinal Sulfur‐containing Tetrasubstituted Stereocenters via Organocatalyzed Mannich‐Type Addition of Rhodanines to Isatin Imines,Advanced Synthesis & Catalysis

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Enantioselective Construction of Vicinal Sulfur‐containing Tetrasubstituted Stereocenters via Organocatalyzed Mannich‐Type Addition of Rhodanines to Isatin Imines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-07-11 , DOI: 10.1002/adsc.201800642
Qiuhong Huang ₁ , Lili Zhang ₁ , Yuyu Cheng ₂ , Pengfei Li ₂ , Wenjun Li ₁

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The catalyzed enantioselective nucleophilic addition of rhodanines has been established by employing isatin‐derived imines as suitable partners under chiral squaramide catalysis. By using this strategy, the resulting 3‐substituted 3‐amino‐2‐oxindoles featuring both rhodanine and vicinal sulfur‐containing tetrasubstituted stereocenters structural motifs were obtained in high yields with excellent enantioselectivities and diastereoselectivities.

中文翻译：

通过有机催化曼丹尼奇型罗丹宁类向亚胺的加成反应，构建对含硫四取代立体中心的对映选择性。

罗丹烷的催化对映体选择性亲核加成反应是通过在手性方酰胺催化下，使用以伊斯兰为基础的亚胺作为合适的配体而建立的。通过使用该策略，可以高收率获得具有出色的对映选择性和非对映选择性的具有罗丹宁和邻位硫的四取代立体中心结构基序的3-取代的3-氨基-2-氧吲哚。

更新日期：2018-07-11

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