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Staurosporine: new lease of life for parent compound of today's novel and highly successful anti-cancer drugs.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2018-Aug-01 , DOI: 10.1038/s41429-018-0029-z
Satoshi Ōmura , Yukihiro Asami , Andy Crump

Staurosporine, together with such examples as penicillin, aspirin, ivermectin and sildenafil, exemplifies the role that serendipity has in drug discovery and why 'finding things without actually searching for them' retains a prominent role in drug discovery. Hitherto not clinically useful, due to its potency and promiscuity, new delivery technology is opening up new horizons for what was previously just the parent compound of innovative, highly-successful anti-cancer agents.

中文翻译:

Staurosporine:当今新颖且非常成功的抗癌药物的母体化合物的新生命。

星形孢菌素与青霉素,阿司匹林,伊维菌素和西地那非等实例一起证明了偶然性在药物发现中的作用,以及为什么“在不实际寻找它们的情况下发现事物”在药物发现中仍占有重要地位。迄今为止,由于其效力和滥交性,迄今在临床上没有用,新的递送技术为以前仅仅是创新的,成功的抗癌药的母体化合物开辟了新的前景。
更新日期:2018-06-22
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