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Substantial Enhancement of the Antioxidant Capacity of an α-Linolenic Acid Loaded Microemulsion: Chemical Manipulation of the Oil–Water Interface by Carbon Dots and Its Potential Application
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-06-22 00:00:00 , DOI: 10.1021/acs.jafc.8b01991 Mengna Hou 1 , Qing Li 1 , Xiaoxue Liu 1 , Chao Lu 1 , Sen Li 1 , Zhanzhong Wang 1 , Leping Dang 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-06-22 00:00:00 , DOI: 10.1021/acs.jafc.8b01991 Mengna Hou 1 , Qing Li 1 , Xiaoxue Liu 1 , Chao Lu 1 , Sen Li 1 , Zhanzhong Wang 1 , Leping Dang 1
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Various active ingredients play a crucial role in providing and supplementing the nutritional requirements of organisms. In this work, we attempted to chemically manipulate the interfacial microstructure of oil–water microemulsions (ME) with carbon dots (CDs), concentrating on substantially enhancing the antioxidant capacity of α-linolenic acid (ALA). To this end, CDs were synthesized and introduced into an ME. The molecular interaction of surfactant with CDs was investigated by Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). The microstructure of the ME was monitored by transmission electron microscopy (TEM) and cryo-electron microscopy (cryo-EM). The cryo-EM result showed the oil–water interface in the ME was better defined after the CDs were loaded, and 1H NMR proved the CDs were distributed mainly at the interface. On the basis of these results, interfacial models were proposed. Final evaluation results demonstrated the stabilizing effect and oxidation-inhibition ability of the ALA-loaded ME was substantially enhanced after the introduction of the CDs, indicating a “turn off” effect of the interface. Interestingly, CDs do not affect the in vitro release of ALA, indicating a “turn on” effect of the interface. This work provided a successful interface manipulation with a nanocarrier that can be used for a large diversity of food nutraceuticals.
中文翻译：
大量增强α-亚麻酸微乳液的抗氧化能力：碳点对油水界面的化学处理及其潜在应用
各种活性成分在提供和补充有机体的营养需求方面起着至关重要的作用。在这项工作中，我们尝试化学操作具有碳点（CD）的油水微乳液（ME）的界面微观结构，着重于实质上增强α-亚麻酸（ALA）的抗氧化能力。为此，CD被合成并被引入到ME中。通过傅里叶变换红外光谱（FTIR）和核磁共振（NMR）研究了表面活性剂与CD的分子相互作用。通过透射电子显微镜（TEM）和冷冻电子显微镜（cryo-EM）监测ME的微观结构。冷冻-EM结果表明，加载CD后，ME中的油水界面得到了更好的定义，并且11 H NMR证明CD主要分布在界面上。基于这些结果，提出了界面模型。最终评估结果表明，引入CD后，ALA负载的ME的稳定作用和氧化抑制能力得到了显着提高，表明界面的“关闭”作用。有趣的是，CD不会影响ALA的体外释放，表明该界面具有“开启”作用。这项工作为纳米载体提供了成功的界面处理方法，该载体可用于多种食品保健食品。
更新日期：2018-06-22
中文翻译：
大量增强α-亚麻酸微乳液的抗氧化能力：碳点对油水界面的化学处理及其潜在应用
各种活性成分在提供和补充有机体的营养需求方面起着至关重要的作用。在这项工作中，我们尝试化学操作具有碳点（CD）的油水微乳液（ME）的界面微观结构，着重于实质上增强α-亚麻酸（ALA）的抗氧化能力。为此，CD被合成并被引入到ME中。通过傅里叶变换红外光谱（FTIR）和核磁共振（NMR）研究了表面活性剂与CD的分子相互作用。通过透射电子显微镜（TEM）和冷冻电子显微镜（cryo-EM）监测ME的微观结构。冷冻-EM结果表明，加载CD后，ME中的油水界面得到了更好的定义，并且11 H NMR证明CD主要分布在界面上。基于这些结果，提出了界面模型。最终评估结果表明，引入CD后，ALA负载的ME的稳定作用和氧化抑制能力得到了显着提高，表明界面的“关闭”作用。有趣的是，CD不会影响ALA的体外释放，表明该界面具有“开启”作用。这项工作为纳米载体提供了成功的界面处理方法，该载体可用于多种食品保健食品。
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