Cerium oxide (IV) nanoparticles offer a high redox ability, while maintaining nontoxicity and high stability. Thus, dispersed nanoceria is a promising candidate as antioxidant material for human cells. In this work, we report on a fast and simple one-pot process that yield a final nanoparticle size of 2–4 nm in polar solvents such as water and alcohols. High boiling point solvents, namely, benzyl alcohol and triethylene glycol, are used to obtain high crystalline nanoparticles by thermal and microwave activation. Transmission electron microscopy investigations prove the narrow size distribution of the CeO₂ nanoparticles and show that the shape can be tuned from spherical to cubic using an appropriate precursor. The main objective of this work is to produce nanoparticles, which are well-defined, biocompatible, and stable in highly concentrated colloidal solutions (up to 90 mM) for a long period of time to study their behavior as antioxidant agents in human cells under oxidative stress.

中文翻译：

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生物相容性稳定的CeO ₂纳米粒子作为抗氧化剂的简单合成

氧化铈（IV）纳米粒子具有高氧化还原能力，同时保持了无毒和高稳定性。因此，分散的纳米氧化铈作为人类细胞的抗氧化剂材料是有希望的候选物。在这项工作中，我们报告了一种快速，简单的一锅法工艺，该工艺在极性溶剂（例如水和醇）中产生的最终纳米颗粒尺寸为2-4 nm。高沸点溶剂，即苯甲醇和三甘醇，用于通过热和微波活化获得高结晶度的纳米颗粒。透射电子显微镜研究证明了CeO ₂的窄尺寸分布纳米颗粒，并显示可以使用适当的前体将形状从球形调整为立方。这项工作的主要目的是生产定义明确，生物相容且在高浓度胶体溶液（高达90 mM）中长期稳定的纳米颗粒，以研究其在氧化作用下在人体细胞中作为抗氧化剂的行为。压力。