We report on a Pd-catalyzed carbonylative α-arylation of azlactones derived from alanine, providing facile access to α,α-disubstituted amino acids after an alcoholysis step. A range of aryl iodides proved to be suitable substrates in this formal four-component approach, providing the desired products in good to high yields. Other amino acids, such as methionine, leucine and phenylalanine could be functionalized in a similar manner with this methodology. The possibility for isotope labeling (¹³C, ²H) was demonstrated, as well as chemoselective transformations of the tricarbonyl-containing molecules.

中文翻译：

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Pd催化的内酯羰基化α-芳基化：与α，α-二取代氨基酸形成正式的四组分偶联途径

我们报告了丙氨酸衍生的丙二酮的钯催化羰基化α-芳基化反应，提供了醇解步骤后对α，α-二取代氨基酸的便捷访问。在这种正式的四组分方法中，一系列芳基碘被证明是合适的底物，以高到高收率提供了所需的产物。其他氨基酸，例如蛋氨酸，亮氨酸和苯丙氨酸可以用这种方法以类似的方式进行功能化。证明了同位素标记（¹³ C，² H）的可能性，以及含三羰基分子的化学选择性转化。