Uncontrolled hemorrhage, which typically involves the torso and/or limb junctional zones, remains a great challenge in the prehospital setting. Here, we for the first time report an injectable and superelastic nanofiber rectangle matrix ("peanut") fabricated by a combination of electrospinning, gas foaming, hydrogel coating and crosslinking techniques. The compressed nanofiber peanut is capable of re-expanding to its original shape in atmosphere, water and blood within 10 s. Such nanofiber peanuts exhibit greater capacity of water/blood absorption compared to current commercial products and high efficacy in whole blood clotting assay, in particular for thrombin-immobilized samples. These nanofiber peanuts are capable of being packed into a syringe for injection. Further in vivo tests indicated the effectiveness of nanofiber peanuts for hemostasis in a porcine liver injury model. This new class of nanofiber-based materials may hold great promise for hemostatic applications.

中文翻译：

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可注射和超弹性纳米纤维矩形基质（“花生”）的制造及其在止血中的潜在应用。

不受控制的出血通常涉及躯干和/或四肢交界区，这在院前环境中仍然是一个巨大的挑战。在这里，我们首次报道了一种通过静电纺丝、气体发泡、水凝胶涂层和交联技术相结合制造的可注射超弹性纳米纤维矩形基质（“花生”）。压缩后的纳米纤维花生能够在大气、水和血液中10秒内重新膨胀至原来的形状。与目前的商业产品相比，这种纳米纤维花生表现出更大的水/血吸收能力，并且在全血凝固测定中表现出高效，特别是对于凝血酶固定的样品。这些纳米纤维花生能够装入注射器中进行注射。进一步的体内测试表明纳米纤维花生在猪肝损伤模型中具有止血作用。这种新型纳米纤维材料可能在止血应用中具有广阔的前景。