The reaction of perfluorobiacetyl with thiourea produced 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione, mainly in trans-form, in a yield of ∼60%. 4,5-Dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione(one) were introduced for the first time in the condensation with thiourea in dimethylacetamide at elevated temperature and trifluoromethylated thioxo(oxo)imidazothiazolones were unexpectedly obtained (yield ∼41 − 30%). A similar reaction of 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione(one) with NH₄SCN and 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione with N-alkyl(aryl)ureas and N,N'-dialkyl(diaryl)ureas afforded the same thioxo(oxo)imidazothiazolones (yield ∼50 − 16%). In contrast to it, the condensation of 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidine-2-thione with urea under similar conditions gave mainly trifluoromethylated thioglycoluril in ∼31% yield.

全氟联乙酰与硫脲的反应生成了4,5-二羟基-4,5-双（三氟甲基）咪唑烷-2-硫酮，主要为反式形式，收率为〜60％。首次在高温下与二甲基乙酰胺中的硫脲缩合反应中首次引入4,5-二羟基-4,5-双（三氟甲基）咪唑烷-2-硫酮（一），意外地获得了三氟甲基化的硫代（氧代）咪唑并噻唑酮（收率） 〜41-30％）。4,5-二羟基-4,5-双（三氟甲基）咪唑烷-2-硫酮（一个）与NH ₄ SCN和4,5-二羟基-4,5-双（三氟甲基）咪唑烷-2-硫酮的相似反应具有N-烷基（芳基）脲和N，N'-二烷基（二芳基）脲提供了相同的硫代（氧代）咪唑并噻唑酮（收率约50-16％）。与此相反，在相似的条件下，4,5-二羟基-4,5-双（三氟甲基）咪唑烷-2-硫酮与尿素的缩合反应主要得到三氟甲基化的巯基脲，收率为31％。